Gallstones, cholecystectomy, and the risk for developing pancreatic cancer

Eva S. Schernhammer, D. S. Michaud, M. F. Leitzmann, E. Giovannucci, G. A. Colditz, C. S. Fuchs

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35 Scopus citations


We examined the relation between gallstones, cholecystectomy, and the development of pancreatic cancer in the Nurses Health Study and the Health Professionals Follow-up Study. Among 104856 women and 48 928 men without cancer at baseline, we documented 349 cases of pancreatic cancer during up to 16 years of follow-up. Participants were classified according to a history of gallstones or cholecystectomy. The age-adjusted relative risk of pancreatic cancer following cholecystectomy or diagnosis of gallstones was 1.31 (95% Cl, 0.93-1.83). However, adjustment for other pancreatic cancer risk factors attenuated the association (RR=1.11, 95% Cl, 0.78-1.56); this risk did not increase with increasing time following cholecystectomy or gallstones. Gallstones or cholecystectomy do not appear to be significant risk factors for pancreatic cancer.

Original languageEnglish
Pages (from-to)1081-1084
Number of pages4
JournalBritish Journal of Cancer
Issue number7
StatePublished - 2002


  • Cholecystectomy
  • Gallstones
  • Pancreatic cancer
  • Prospective cohort study
  • Risk factors


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