Gallium-68 Prostate-Specific Membrane Antigen PET Imaging

Michael S. Hofman; Amir Iravani

doi:10.1016/j.cpet.2016.12.004

Gallium-68 Prostate-Specific Membrane Antigen PET Imaging

Michael S. Hofman, Amir Iravani

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The role of gallium-68 (⁶⁸Ga) prostate-specific membrane antigen (PSMA) PET imaging is evolving and finding its place in the imaging armamentarium for prostate cancer (PCa). Despite the progress of conventional imaging strategies, significant limitations remain, including identification of small-volume disease and assessment of bone. Clinical studies have demonstrated that ⁶⁸Ga-PSMA is a promising tracer for detection of PCa metastases, even in patients with low prostate-specific antigen. To provide an accurate interpretation of ⁶⁸Ga-PSMA PET/computed tomography, nuclear medicine specialists and radiologists should be familiar with physiologic ⁶⁸Ga-PSMA uptake, common variants, patterns of locoregional and distant spread of PCa, and inherent pitfalls.

Original language	English
Pages (from-to)	219-234
Number of pages	16
Journal	PET Clinics
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.cpet.2016.12.004
State	Published - Apr 1 2017

Keywords

Ga-PSMA
Ga-PSMA PET
PET
Prostate cancer
Prostate-specific membrane antigen

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10.1016/j.cpet.2016.12.004

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title = "Gallium-68 Prostate-Specific Membrane Antigen PET Imaging",

abstract = "The role of gallium-68 (68Ga) prostate-specific membrane antigen (PSMA) PET imaging is evolving and finding its place in the imaging armamentarium for prostate cancer (PCa). Despite the progress of conventional imaging strategies, significant limitations remain, including identification of small-volume disease and assessment of bone. Clinical studies have demonstrated that 68Ga-PSMA is a promising tracer for detection of PCa metastases, even in patients with low prostate-specific antigen. To provide an accurate interpretation of 68Ga-PSMA PET/computed tomography, nuclear medicine specialists and radiologists should be familiar with physiologic 68Ga-PSMA uptake, common variants, patterns of locoregional and distant spread of PCa, and inherent pitfalls.",

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AU - Iravani, Amir

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N2 - The role of gallium-68 (68Ga) prostate-specific membrane antigen (PSMA) PET imaging is evolving and finding its place in the imaging armamentarium for prostate cancer (PCa). Despite the progress of conventional imaging strategies, significant limitations remain, including identification of small-volume disease and assessment of bone. Clinical studies have demonstrated that 68Ga-PSMA is a promising tracer for detection of PCa metastases, even in patients with low prostate-specific antigen. To provide an accurate interpretation of 68Ga-PSMA PET/computed tomography, nuclear medicine specialists and radiologists should be familiar with physiologic 68Ga-PSMA uptake, common variants, patterns of locoregional and distant spread of PCa, and inherent pitfalls.

AB - The role of gallium-68 (68Ga) prostate-specific membrane antigen (PSMA) PET imaging is evolving and finding its place in the imaging armamentarium for prostate cancer (PCa). Despite the progress of conventional imaging strategies, significant limitations remain, including identification of small-volume disease and assessment of bone. Clinical studies have demonstrated that 68Ga-PSMA is a promising tracer for detection of PCa metastases, even in patients with low prostate-specific antigen. To provide an accurate interpretation of 68Ga-PSMA PET/computed tomography, nuclear medicine specialists and radiologists should be familiar with physiologic 68Ga-PSMA uptake, common variants, patterns of locoregional and distant spread of PCa, and inherent pitfalls.

KW - Ga-PSMA

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KW - PET

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Gallium-68 Prostate-Specific Membrane Antigen PET Imaging

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Keywords

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