Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

Michael L. Patnode; Chu Wen Cheng; Chi Chi Chou; Mark S. Singer; Matilda S. Elin; Kenji Uchimura; Paul R. Crocker; Kay Hooi Khoo; Steven D. Rosen

doi:10.1074/jbc.M113.485409

Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

Michael L. Patnode
, Chu Wen Cheng
, Chi Chi Chou
, Mark S. Singer
, Matilda S. Elin
, Kenji Uchimura
, Paul R. Crocker
, Kay Hooi Khoo
, Steven D. Rosen

Department of Pathology & Immunology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.

Original language	English
Pages (from-to)	26533-26545
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.485409
State	Published - Sep 13 2013

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title = "Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue",

abstract = "Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.",

author = "Patnode, \{Michael L.\} and Cheng, \{Chu Wen\} and Chou, \{Chi Chi\} and Singer, \{Mark S.\} and Elin, \{Matilda S.\} and Kenji Uchimura and Crocker, \{Paul R.\} and Khoo, \{Kay Hooi\} and Rosen, \{Steven D.\}",

year = "2013",

month = sep,

day = "13",

doi = "10.1074/jbc.M113.485409",

language = "English",

volume = "288",

pages = "26533--26545",

journal = "Journal of Biological Chemistry",

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T1 - Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

AU - Patnode, Michael L.

AU - Cheng, Chu Wen

AU - Chou, Chi Chi

AU - Singer, Mark S.

AU - Elin, Matilda S.

AU - Uchimura, Kenji

AU - Crocker, Paul R.

AU - Khoo, Kay Hooi

AU - Rosen, Steven D.

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.

AB - Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.

UR - https://www.scopus.com/pages/publications/84884170237

U2 - 10.1074/jbc.M113.485409

DO - 10.1074/jbc.M113.485409

M3 - Article

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AN - SCOPUS:84884170237

SN - 0021-9258

VL - 288

SP - 26533

EP - 26545

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 37

ER -

Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

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