Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.
|Number of pages||13|
|Journal||Journal of Biological Chemistry|
|State||Published - Sep 13 2013|