Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

Michael L. Patnode; Chu Wen Cheng; Chi Chi Chou; Mark S. Singer; Matilda S. Elin; Kenji Uchimura; Paul R. Crocker; Kay Hooi Khoo; Steven D. Rosen

doi:10.1074/jbc.M113.485409

Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

Michael L. Patnode, Chu Wen Cheng, Chi Chi Chou, Mark S. Singer, Matilda S. Elin, Kenji Uchimura, Paul R. Crocker, Kay Hooi Khoo, Steven D. Rosen

Department of Pathology & Immunology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.

Original language	English
Pages (from-to)	26533-26545
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.485409
State	Published - Sep 13 2013

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title = "Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue",

abstract = "Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.",

author = "Patnode, {Michael L.} and Cheng, {Chu Wen} and Chou, {Chi Chi} and Singer, {Mark S.} and Elin, {Matilda S.} and Kenji Uchimura and Crocker, {Paul R.} and Khoo, {Kay Hooi} and Rosen, {Steven D.}",

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doi = "10.1074/jbc.M113.485409",

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T1 - Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

AU - Patnode, Michael L.

AU - Cheng, Chu Wen

AU - Chou, Chi Chi

AU - Singer, Mark S.

AU - Elin, Matilda S.

AU - Uchimura, Kenji

AU - Crocker, Paul R.

AU - Khoo, Kay Hooi

AU - Rosen, Steven D.

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.

AB - Background: The cell surface lectin Siglec-F is thought to preferentially recognize ligands modified with galactose 6-O-sulfate. Results: Siglec-F ligands are still present in leukocytes and lung tissue from mice lacking galactose 6-O-sulfotransferases. Conclusion: Ligands are restricted to specific cell types, but galactose 6-O-sulfotransferases are not required for ligand binding. Significance: This study refines our understanding of the biological ligands for Siglec-F.

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U2 - 10.1074/jbc.M113.485409

DO - 10.1074/jbc.M113.485409

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SN - 0021-9258

VL - 288

SP - 26533

EP - 26545

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 37

ER -

Galactose 6-O-sulfotransferases are not required for the generation of siglec-F ligands in leukocytes or lung tissue

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