Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent

Zhiliang Cheng; Daniel L.J. Thorek; Andrew Tsourkas

doi:10.1002/anie.200905133

Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T ₁ magnetic resonance imaging contrast agent

Zhiliang Cheng, Daniel L.J. Thorek, Andrew Tsourkas

Research output: Contribution to journal › Article › peer-review

184 Scopus citations

Abstract

"Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

Original language	English
Pages (from-to)	346-350
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	2
DOIs	https://doi.org/10.1002/anie.200905133
State	Published - Jan 8 2010

Keywords

Dendrimers
Gadolinium
Imaging agents
Magnetic resonance imaging
Tumors

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10.1002/anie.200905133

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title = "Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent",

abstract = "{"}Chemical Equation Presented{"} Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).",

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AU - Cheng, Zhiliang

AU - Thorek, Daniel L.J.

AU - Tsourkas, Andrew

PY - 2010/1/8

Y1 - 2010/1/8

N2 - "Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

AB - "Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

KW - Dendrimers

KW - Gadolinium

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Tumors

UR - https://www.scopus.com/pages/publications/73349083082

U2 - 10.1002/anie.200905133

DO - 10.1002/anie.200905133

M3 - Article

C2 - 19967688

AN - SCOPUS:73349083082

SN - 1433-7851

VL - 49

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 2

ER -

Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T ₁ magnetic resonance imaging contrast agent

Abstract

Keywords

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