Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent

Zhiliang Cheng; Daniel L.J. Thorek; Andrew Tsourkas

doi:10.1002/anie.200905133

Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T ₁ magnetic resonance imaging contrast agent

Zhiliang Cheng, Daniel L.J. Thorek, Andrew Tsourkas

Research output: Contribution to journal › Article › peer-review

182 Scopus citations

Abstract

"Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

Original language	English
Pages (from-to)	346-350
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	2
DOIs	https://doi.org/10.1002/anie.200905133
State	Published - Jan 8 2010

Keywords

Dendrimers
Gadolinium
Imaging agents
Magnetic resonance imaging
Tumors

Access to Document

10.1002/anie.200905133

Cite this

@article{bd7cdc26fe3f4d70a5c831a643df518d,

title = "Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent",

abstract = "{"}Chemical Equation Presented{"} Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).",

keywords = "Dendrimers, Gadolinium, Imaging agents, Magnetic resonance imaging, Tumors",

author = "Zhiliang Cheng and Thorek, {Daniel L.J.} and Andrew Tsourkas",

year = "2010",

month = jan,

day = "8",

doi = "10.1002/anie.200905133",

language = "English",

volume = "49",

pages = "346--350",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

number = "2",

}

TY - JOUR

T1 - Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent

AU - Cheng, Zhiliang

AU - Thorek, Daniel L.J.

AU - Tsourkas, Andrew

PY - 2010/1/8

Y1 - 2010/1/8

N2 - "Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

AB - "Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

KW - Dendrimers

KW - Gadolinium

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Tumors

UR - http://www.scopus.com/inward/record.url?scp=73349083082&partnerID=8YFLogxK

U2 - 10.1002/anie.200905133

DO - 10.1002/anie.200905133

M3 - Article

C2 - 19967688

AN - SCOPUS:73349083082

SN - 1433-7851

VL - 49

SP - 346

EP - 350

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 2

ER -

Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T ₁ magnetic resonance imaging contrast agent

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this