TY - JOUR
T1 - Gabapentin as Adjunctive Therapy in Neonatal Opioid Withdrawal Syndrome
T2 - A Case Series
AU - Patz, Caroline
AU - Liviskie, Caren
AU - Bird, Merielle
AU - Zeller, Brandy
AU - Vesoulis, Zachary A.
AU - Smyser, Christopher D.
AU - McPherson, Christopher
N1 - Publisher Copyright:
© Pediatric Pharmacy Association. All rights reserved.
PY - 2023
Y1 - 2023
N2 - OBJECTIVE We describe a single center experience with gabapentin as adjunctive therapy in infants with neonatal opioid withdrawal syndrome (NOWS). METHODS We performed a retrospective chart review of infants receiving gabapentin for NOWS. Data points collected included patient’s sex, gestational age, maternal opioid exposure, NOWS medication dosing and length of therapy, number of failed wean attempts, time to successful morphine wean and duration of morphine wean, length of stay in the neonatal intensive care unit (NICU), and NOWS medications at discharge. RESULTS Six infants received gabapentin as adjunctive treatment for NOWS. All infants failed 2–4 morphine weans before initiation of gabapentin despite the addition of clonidine. All infants that received gabapentin were successfully weaned off morphine. The time to wean off morphine after gabapentin initiation varied from 4–35 days. Maximum gabapentin doses ranged from 15 – 42.7 mg/kg/day. Five infants were discharged from the NICU on gabapentin. CONCLUSIONS Gabapentin appeared to facilitate successful morphine weans in six patients with NOWS who were previously unable to wean despite the initiation of clonidine.
AB - OBJECTIVE We describe a single center experience with gabapentin as adjunctive therapy in infants with neonatal opioid withdrawal syndrome (NOWS). METHODS We performed a retrospective chart review of infants receiving gabapentin for NOWS. Data points collected included patient’s sex, gestational age, maternal opioid exposure, NOWS medication dosing and length of therapy, number of failed wean attempts, time to successful morphine wean and duration of morphine wean, length of stay in the neonatal intensive care unit (NICU), and NOWS medications at discharge. RESULTS Six infants received gabapentin as adjunctive treatment for NOWS. All infants failed 2–4 morphine weans before initiation of gabapentin despite the addition of clonidine. All infants that received gabapentin were successfully weaned off morphine. The time to wean off morphine after gabapentin initiation varied from 4–35 days. Maximum gabapentin doses ranged from 15 – 42.7 mg/kg/day. Five infants were discharged from the NICU on gabapentin. CONCLUSIONS Gabapentin appeared to facilitate successful morphine weans in six patients with NOWS who were previously unable to wean despite the initiation of clonidine.
KW - case series
KW - clonidine
KW - gabapentin
KW - morphine
KW - neonatal abstinence syndrome
KW - neonatal opioid withdrawal syndrome
UR - http://www.scopus.com/inward/record.url?scp=85168101820&partnerID=8YFLogxK
U2 - 10.5863/1551-6776-28.4.368
DO - 10.5863/1551-6776-28.4.368
M3 - Article
C2 - 37795276
AN - SCOPUS:85168101820
SN - 1551-6776
VL - 28
SP - 368
EP - 373
JO - Journal of Pediatric Pharmacology and Therapeutics
JF - Journal of Pediatric Pharmacology and Therapeutics
IS - 4
ER -