G proteins in heart disease

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Heterotrimeric G proteins are the signal transducers for seven transmembrane spanning receptors, enabling receptor activation of individual downstream signaling pathways. Modified expression or activity of G proteins and their downstream effectors is postulated to play a role in cardiac hypertrophy and heart failure. This paper reviews the evidence for and against a pathologic role for G proteins in cardiac disease.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalHeart Failure Reviews
Volume4
Issue number4
DOIs
StatePublished - 1999

Keywords

  • Cell signaling
  • Heart failure
  • Hypertrophy

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