Abstract
Heterotrimeric G proteins are the signal transducers for seven transmembrane spanning receptors, enabling receptor activation of individual downstream signaling pathways. Modified expression or activity of G proteins and their downstream effectors is postulated to play a role in cardiac hypertrophy and heart failure. This paper reviews the evidence for and against a pathologic role for G proteins in cardiac disease.
| Original language | English |
|---|---|
| Pages (from-to) | 303-310 |
| Number of pages | 8 |
| Journal | Heart Failure Reviews |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1999 |
Keywords
- Cell signaling
- Heart failure
- Hypertrophy