Heterotrimeric G proteins are the signal transducers for seven transmembrane spanning receptors, enabling receptor activation of individual downstream signaling pathways. Modified expression or activity of G proteins and their downstream effectors is postulated to play a role in cardiac hypertrophy and heart failure. This paper reviews the evidence for and against a pathologic role for G proteins in cardiac disease.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalHeart Failure Reviews
Issue number4
StatePublished - 1999


  • Cell signaling
  • Heart failure
  • Hypertrophy


Dive into the research topics of 'G proteins in heart disease'. Together they form a unique fingerprint.

Cite this