Fyn in Neurodevelopment and Ischemic Brain Injury

Renatta Knox, Xiangning Jiang

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The Src family kinases (SFKs) are nonreceptor protein tyrosine kinases that are implicated in many normal and pathological processes in the nervous system. The SFKs Fyn, Src, Yes, Lyn, and Lck are expressed in the brain. This review will focus on Fyn, as Fyn mutant mice have striking phenotypes in the brain and Fyn has been shown to be involved in ischemic brain injury in adult rodents and, with our work, in neonatal animals. An understanding of Fyn's role in neurodevelopment and disease will allow researchers to target pathological pathways while preserving protective ones.

Original languageEnglish
Pages (from-to)311-320
Number of pages10
JournalDevelopmental Neuroscience
Issue number4-5
StatePublished - Jul 25 2015


  • Brain
  • Development
  • Fyn tyrosine kinase
  • Ischemia


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