Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study

Mmadili N. Ilozumba; Tengda Lin; Sheetal Hardikar; Doratha A. Byrd; June L. Round; W. Zac Stephens; Andreana N. Holowatyj; Christy A. Warby; Victoria Damerell; Christopher I. Li; Jane C. Figueiredo; Adetunji T. Toriola; David Shibata; Gary C. Fillmore; Bartley Pickron; Erin M. Siegel; Christoph Kahlert; Vaia Florou; Biljana Gigic; Jennifer Ose; Cornelia M. Ulrich

doi:10.1002/cam4.70431

Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study

Mmadili N. Ilozumba, Tengda Lin, Sheetal Hardikar, Doratha A. Byrd, June L. Round, W. Zac Stephens, Andreana N. Holowatyj, Christy A. Warby, Victoria Damerell, Christopher I. Li, Jane C. Figueiredo, Adetunji T. Toriola, David Shibata, Gary C. Fillmore, Bartley Pickron, Erin M. Siegel, Christoph Kahlert, Vaia Florou, Biljana Gigic, Jennifer OseCornelia M. Ulrich

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established. Methods: We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I–III CRC in the ColoCare Study. Results: High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03). Conclusion: Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.

Original language	English
Article number	e70431
Journal	Cancer medicine
Volume	13
Issue number	22
DOIs	https://doi.org/10.1002/cam4.70431
State	Published - Nov 2024

Keywords

Fusobacterium nucleatum
cachexia
colorectal cancer

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10.1002/cam4.70431

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Ilozumba, M. N., Lin, T., Hardikar, S., Byrd, D. A., Round, J. L., Stephens, W. Z., Holowatyj, A. N., Warby, C. A., Damerell, V., Li, C. I., Figueiredo, J. C., Toriola, A. T., Shibata, D., Fillmore, G. C., Pickron, B., Siegel, E. M., Kahlert, C., Florou, V., Gigic, B., ... Ulrich, C. M. (2024). Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study. Cancer medicine, 13(22), Article e70431. https://doi.org/10.1002/cam4.70431

@article{25388f0fa6a94e4992e6f9a09f90df1c,

title = "Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study",

abstract = "Background: Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established. Methods: We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I–III CRC in the ColoCare Study. Results: High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03). Conclusion: Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.",

keywords = "Fusobacterium nucleatum, cachexia, colorectal cancer",

author = "Ilozumba, {Mmadili N.} and Tengda Lin and Sheetal Hardikar and Byrd, {Doratha A.} and Round, {June L.} and Stephens, {W. Zac} and Holowatyj, {Andreana N.} and Warby, {Christy A.} and Victoria Damerell and Li, {Christopher I.} and Figueiredo, {Jane C.} and Toriola, {Adetunji T.} and David Shibata and Fillmore, {Gary C.} and Bartley Pickron and Siegel, {Erin M.} and Christoph Kahlert and Vaia Florou and Biljana Gigic and Jennifer Ose and Ulrich, {Cornelia M.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.",

year = "2024",

month = nov,

doi = "10.1002/cam4.70431",

language = "English",

volume = "13",

journal = "Cancer medicine",

issn = "2045-7634",

number = "22",

}

Ilozumba, MN, Lin, T, Hardikar, S, Byrd, DA, Round, JL, Stephens, WZ, Holowatyj, AN, Warby, CA, Damerell, V, Li, CI, Figueiredo, JC, Toriola, AT, Shibata, D, Fillmore, GC, Pickron, B, Siegel, EM, Kahlert, C, Florou, V, Gigic, B, Ose, J & Ulrich, CM 2024, 'Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study', Cancer medicine, vol. 13, no. 22, e70431. https://doi.org/10.1002/cam4.70431

TY - JOUR

T1 - Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients

T2 - The ColoCare Study

AU - Ilozumba, Mmadili N.

AU - Lin, Tengda

AU - Hardikar, Sheetal

AU - Byrd, Doratha A.

AU - Round, June L.

AU - Stephens, W. Zac

AU - Holowatyj, Andreana N.

AU - Warby, Christy A.

AU - Damerell, Victoria

AU - Li, Christopher I.

AU - Figueiredo, Jane C.

AU - Toriola, Adetunji T.

AU - Shibata, David

AU - Fillmore, Gary C.

AU - Pickron, Bartley

AU - Siegel, Erin M.

AU - Kahlert, Christoph

AU - Florou, Vaia

AU - Gigic, Biljana

AU - Ose, Jennifer

AU - Ulrich, Cornelia M.

PY - 2024/11

Y1 - 2024/11

N2 - Background: Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established. Methods: We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I–III CRC in the ColoCare Study. Results: High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03). Conclusion: Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.

AB - Background: Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established. Methods: We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I–III CRC in the ColoCare Study. Results: High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03). Conclusion: Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.

KW - Fusobacterium nucleatum

KW - cachexia

KW - colorectal cancer

UR - http://www.scopus.com/inward/record.url?scp=85210180790&partnerID=8YFLogxK

U2 - 10.1002/cam4.70431

DO - 10.1002/cam4.70431

M3 - Article

C2 - 39587707

AN - SCOPUS:85210180790

SN - 2045-7634

VL - 13

JO - Cancer medicine

JF - Cancer medicine

IS - 22

M1 - e70431

ER -

Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study

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