FUS Zigzags Its Way to Cross Beta

Alex S. Holehouse, Rohit V. Pappu

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones. The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones.

Original languageEnglish
Pages (from-to)499-500
Number of pages2
JournalCell
Volume171
Issue number3
DOIs
StatePublished - Oct 19 2017

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