Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7

Shana R. Leopold; Nurmohammad Shaikh; Phillip I. Tarr

doi:10.1016/j.meegid.2010.07.021

Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7

Shana R. Leopold
, Nurmohammad Shaikh
, Phillip I. Tarr

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Escherichia coli O157:H7 is a human pathogen that has emerged from its less pathogenic progenitor, E. coli O55:H7, to form the EHEC 1 clade. In its emergence, E. coli O157:H7 formed three distinct clusters, each of which exists today. Sequencing and SNP analysis of Cluster 1 of this clade demonstrated constrained radiation from the cluster founder. Here we investigated the diversity of Cluster 2 strains by sequencing signature SNPs in six strains collected throughout Washington State. Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade.

Original language	English
Pages (from-to)	1282-1285
Number of pages	4
Journal	Infection, Genetics and Evolution
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/j.meegid.2010.07.021
State	Published - Dec 2010

Keywords

Escherichia coli O157:H7
Evolution
SNPs

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10.1016/j.meegid.2010.07.021

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title = "Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7",

abstract = "Escherichia coli O157:H7 is a human pathogen that has emerged from its less pathogenic progenitor, E. coli O55:H7, to form the EHEC 1 clade. In its emergence, E. coli O157:H7 formed three distinct clusters, each of which exists today. Sequencing and SNP analysis of Cluster 1 of this clade demonstrated constrained radiation from the cluster founder. Here we investigated the diversity of Cluster 2 strains by sequencing signature SNPs in six strains collected throughout Washington State. Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade.",

keywords = "Escherichia coli O157:H7, Evolution, SNPs",

author = "Leopold, \{Shana R.\} and Nurmohammad Shaikh and Tarr, \{Phillip I.\}",

note = "Funding Information: We are grateful to the late Thomas Whittam for helpful discussions on bacterial evolution that formed the basis for our study. This work was supported by National Institutes of Health Grants AI47499, R56AI063282, and DK52081 (to P.I.T.); 5P30 DK052574 (to Washington University Digestive Diseases Research Core Center Biobank); and 5T32AI007172 (to S.R.L.).",

year = "2010",

month = dec,

doi = "10.1016/j.meegid.2010.07.021",

language = "English",

volume = "10",

pages = "1282--1285",

journal = "Infection, Genetics and Evolution",

issn = "1567-1348",

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T1 - Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7

AU - Leopold, Shana R.

AU - Shaikh, Nurmohammad

AU - Tarr, Phillip I.

N1 - Funding Information: We are grateful to the late Thomas Whittam for helpful discussions on bacterial evolution that formed the basis for our study. This work was supported by National Institutes of Health Grants AI47499, R56AI063282, and DK52081 (to P.I.T.); 5P30 DK052574 (to Washington University Digestive Diseases Research Core Center Biobank); and 5T32AI007172 (to S.R.L.).

PY - 2010/12

Y1 - 2010/12

N2 - Escherichia coli O157:H7 is a human pathogen that has emerged from its less pathogenic progenitor, E. coli O55:H7, to form the EHEC 1 clade. In its emergence, E. coli O157:H7 formed three distinct clusters, each of which exists today. Sequencing and SNP analysis of Cluster 1 of this clade demonstrated constrained radiation from the cluster founder. Here we investigated the diversity of Cluster 2 strains by sequencing signature SNPs in six strains collected throughout Washington State. Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade.

AB - Escherichia coli O157:H7 is a human pathogen that has emerged from its less pathogenic progenitor, E. coli O55:H7, to form the EHEC 1 clade. In its emergence, E. coli O157:H7 formed three distinct clusters, each of which exists today. Sequencing and SNP analysis of Cluster 1 of this clade demonstrated constrained radiation from the cluster founder. Here we investigated the diversity of Cluster 2 strains by sequencing signature SNPs in six strains collected throughout Washington State. Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade.

KW - Escherichia coli O157:H7

KW - Evolution

KW - SNPs

UR - https://www.scopus.com/pages/publications/77957304223

U2 - 10.1016/j.meegid.2010.07.021

DO - 10.1016/j.meegid.2010.07.021

M3 - Article

C2 - 20691811

AN - SCOPUS:77957304223

SN - 1567-1348

VL - 10

SP - 1282

EP - 1285

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

IS - 8

ER -

Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7

Abstract

Keywords

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