Abstract
Escherichia coli O157:H7 is a human pathogen that has emerged from its less pathogenic progenitor, E. coli O55:H7, to form the EHEC 1 clade. In its emergence, E. coli O157:H7 formed three distinct clusters, each of which exists today. Sequencing and SNP analysis of Cluster 1 of this clade demonstrated constrained radiation from the cluster founder. Here we investigated the diversity of Cluster 2 strains by sequencing signature SNPs in six strains collected throughout Washington State. Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade.
| Original language | English |
|---|---|
| Pages (from-to) | 1282-1285 |
| Number of pages | 4 |
| Journal | Infection, Genetics and Evolution |
| Volume | 10 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 1 2010 |
Keywords
- Escherichia coli O157:H7
- Evolution
- SNPs
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Leopold, S. R., Shaikh, N., & Tarr, P. I. (2010). Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7. Infection, Genetics and Evolution, 10(8), 1282-1285. https://doi.org/10.1016/j.meegid.2010.07.021