Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7

Shana R. Leopold, Nurmohammad Shaikh, Phillip I. Tarr

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Escherichia coli O157:H7 is a human pathogen that has emerged from its less pathogenic progenitor, E. coli O55:H7, to form the EHEC 1 clade. In its emergence, E. coli O157:H7 formed three distinct clusters, each of which exists today. Sequencing and SNP analysis of Cluster 1 of this clade demonstrated constrained radiation from the cluster founder. Here we investigated the diversity of Cluster 2 strains by sequencing signature SNPs in six strains collected throughout Washington State. Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade.

Original languageEnglish
Pages (from-to)1282-1285
Number of pages4
JournalInfection, Genetics and Evolution
Volume10
Issue number8
DOIs
StatePublished - Dec 1 2010

Keywords

  • Escherichia coli O157:H7
  • Evolution
  • SNPs

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