Further analyses of the NIMH bipolar dataset: Follow up on suggestive linkage results on 1p and 10p

J. Corbett, J. Rice, N. Saccone, A. Goate, T. Reich, T. Foroud, J. Nurnberger, H. Edenberg, J. R. DePaulo, E. Gershon

Research output: Contribution to journalArticlepeer-review


Bipolar Affective Disorder (BP) is complex and familial. However, the genetics of BP is not consistent with a major locus inheritance. Linkage of BP has been reported in several chromosomal regions. Data from 540 subjects from 97 families in wave one of a four site collaborative study supported as part of the NIMH genetics initiative indicated possible linkage to a region on chromosome 1 near D1S224 (MOD 1.66, p<0.001) as well as regions on chromosome 10 near D10S1423 (MOD 3.40, p<0.001) and D10S188 (MOD 3.47, p<0.001). Ascertainment required a subject affected with Bipolar I disorder (BP1) and another subject with BP1 or schizoaffective disorder, bipolar type (SA/BP). Subjects were considered affected if diagnosed with BP1, SA/BP, or Bipolar II disorder (BP2). Additional markers were then genotyped in a 20cm region around D1S224. With these new markers and additional genotyping of 353 individuals from 56 families in wave 2 of the study, there is no longer suggestive evidence for linkage to D1S224. Using Mapmaker/Sibs, a multipoint analysis using the all pairs unweighted option yields a maximal lod score of 0.96 near D1S224. Evidence for linkage on 10p remains strong with an all pairs unweighted lod score of 4.48 near D10S1423.

Original languageEnglish
Pages (from-to)469
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number4
StatePublished - Aug 7 2000


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