TY - JOUR
T1 - Funding Peyronie’s disease
T2 - funding sources for primary research literature
AU - Christiansen, Andrew
AU - Smelser, Woodson
AU - Broghammer, Joshua
AU - Deibert, Christopher M.
N1 - Funding Information:
The ten articles sponsored by NIH-related funding (total US$105,566,456) were further reviewed using the NIH RePORTER database. The articles were supported by 11 core projects comprising a total of 190 awards from 5 NIH institutes, such that some articles had multiple NIH funding sources (Table 2). The NIDDK was the most frequent sponsoring institute supporting 8/10 articles. Most of the funding was related to erectile and sexual dysfunction projects with US$389,775 in PD-specific grant funding to a single investigator during the years examined.
Funding Information:
Table 2 Funding for NIH sponsored projects by administering institute.
Funding Information:
The vast majority of PD research appears largely investigator funded. NIH funding has contributed only 2.3% of the funding within this disease group. Using the NIH RePORTER we discovered that much of the $105 million of NIH funding listed in the PD publications is actually a grant for erectile dysfunction related projects. The investigators and their labs or fellowships are supported by these NIH grants and the PD research is an offshoot of this support. The majority of funding for erectile dysfunction was granted for pathophysiology research with animal models. Only US $389,000 NIH funding was directly granted to support PD basic science research while there were no NIH projects on prevention or therapy development. In general, the field of urology has the least number of NIH funded grants of other surgical subspecialties [4].
Funding Information:
PD research remains mostly investigator funded with little provided by the NIH or industry. Most articles focus on surgical therapy, pathophysiology, or intralesional therapy. Opportunities for grant applications and funding approval, both at the NIH and elsewhere, should be pursued.
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2021/1
Y1 - 2021/1
N2 - The objective was to describe funding sources and publication trends for the primary literature on Peyronie’s disease (PD), including direct industry research support. A search of EMBASE, PubMed, Scopus, and Web of Science was performed to identify articles published from 2006 to 2018. Articles not published in English, reviews, case reports, editorials, guidelines, and meta-analysis were excluded from analysis. Data collected included year and journal of publication, major focus, and funding sources. The US Federal Open Payments database was searched for direct industry research payments to authors. Four hundred thirty-seven articles met criteria. The median number of yearly publications was 31. The most frequent publications were Journal of Sexual Medicine (25.6%), Urology (8.9%), BJU International (7.3%), and Journal of Urology (5.7%). Plaque excision/grafting was the most common topic (16.5%) followed by pathophysiology (15.3%), and intralesional therapy (14.9%). Only 15.1% (n = 66) of articles had a funding source with only 2.3% (n = 10) articles receiving any National Institutes of Health (NIH) funding. In total, 4.1% (n = 18) of the articles were industry funded, 61.1% (n = 11) of these from Xiaflex manufacturer Endo/Auxilium. Remaining articles appeared self-funded. There were 1524 unique authors and just 13 received any direct industry funds, totaling US$718,426. Most PD research is self-funded with only a small percentage from NIH or industry.
AB - The objective was to describe funding sources and publication trends for the primary literature on Peyronie’s disease (PD), including direct industry research support. A search of EMBASE, PubMed, Scopus, and Web of Science was performed to identify articles published from 2006 to 2018. Articles not published in English, reviews, case reports, editorials, guidelines, and meta-analysis were excluded from analysis. Data collected included year and journal of publication, major focus, and funding sources. The US Federal Open Payments database was searched for direct industry research payments to authors. Four hundred thirty-seven articles met criteria. The median number of yearly publications was 31. The most frequent publications were Journal of Sexual Medicine (25.6%), Urology (8.9%), BJU International (7.3%), and Journal of Urology (5.7%). Plaque excision/grafting was the most common topic (16.5%) followed by pathophysiology (15.3%), and intralesional therapy (14.9%). Only 15.1% (n = 66) of articles had a funding source with only 2.3% (n = 10) articles receiving any National Institutes of Health (NIH) funding. In total, 4.1% (n = 18) of the articles were industry funded, 61.1% (n = 11) of these from Xiaflex manufacturer Endo/Auxilium. Remaining articles appeared self-funded. There were 1524 unique authors and just 13 received any direct industry funds, totaling US$718,426. Most PD research is self-funded with only a small percentage from NIH or industry.
UR - http://www.scopus.com/inward/record.url?scp=85081679856&partnerID=8YFLogxK
U2 - 10.1038/s41443-020-0244-6
DO - 10.1038/s41443-020-0244-6
M3 - Article
C2 - 32152470
AN - SCOPUS:85081679856
SN - 0955-9930
VL - 33
SP - 82
EP - 85
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research
IS - 1
ER -