Fundamentals of neurogastroenterology

Jakie D. Wood, D. H. Alpers, P. L.R. Andrews

Research output: Contribution to journalReview articlepeer-review

280 Scopus citations


Current concepts and basic principles of neurogastroenterology in relation to functional gastrointestinal disorders are reviewed. Neurogastroenterology is emphasized as a new and advancing subspecialty of clinical gastroenterology and digestive science. As such, it embraces the investigative sciences dealing with functions, malfunctions, and malformations in the brain and spinal cord, and the sympathetic, parasympathetic and enteric divisions of the autonomic innervation of the digestive tract. Somatomotor systems are included insofar as pharyngeal phases of swallowing and pelvic floor involvement in defecation, continences and pelvic pain are concerned. Inclusion of basic physiology of smooth muscles mucosal epitheliums and the enteric immune system in the neurogastroenterologic domain relates to requirements for compatibility with neural control mechanisms. Psychologic and psychiatric relations to functional gastrointestinal disorders are included because they are significant components of neurogastroenterology, especially in relation to projections of discomfort and pain to the digestive tract.

Original languageEnglish
Pages (from-to)II6-II16
Issue numberSUPPL. 2
StatePublished - 1999


  • Autonomic nervous system
  • Brain-gut axis
  • Enteric nervous system
  • Gastrointestinal pain
  • Gut motility
  • Mast cells
  • Nausea
  • Rome II


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