Functions of Murine Dendritic Cells

Vivek Durai; Kenneth M. Murphy

doi:10.1016/j.immuni.2016.10.010

Functions of Murine Dendritic Cells

Vivek Durai, Kenneth M. Murphy

Research output: Contribution to journal › Review article › peer-review

300 Scopus citations

Abstract

Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating adaptive immune responses. The functions of DCs were originally obscured by their overlap with other mononuclear phagocytes, but new mouse models have allowed for the selective ablation of subsets of DCs and have helped to identify their non-redundant roles in the immune system. These tools have elucidated the functions of DCs in host defense against pathogens, autoimmunity, and cancer. This review will describe the mouse models generated to interrogate the role of DCs and will discuss how their use has progressively clarified our understanding of the unique functions of DC subsets.

Original language	English
Pages (from-to)	719-736
Number of pages	18
Journal	Immunity
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2016.10.010
State	Published - Oct 18 2016

Access to Document

10.1016/j.immuni.2016.10.010

Cite this

@article{5aa072e637644df59c5fe565ba37329d,

title = "Functions of Murine Dendritic Cells",

abstract = "Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating adaptive immune responses. The functions of DCs were originally obscured by their overlap with other mononuclear phagocytes, but new mouse models have allowed for the selective ablation of subsets of DCs and have helped to identify their non-redundant roles in the immune system. These tools have elucidated the functions of DCs in host defense against pathogens, autoimmunity, and cancer. This review will describe the mouse models generated to interrogate the role of DCs and will discuss how their use has progressively clarified our understanding of the unique functions of DC subsets.",

author = "Vivek Durai and Murphy, {Kenneth M.}",

note = "Publisher Copyright: {\textcopyright} 2016",

year = "2016",

month = oct,

day = "18",

doi = "10.1016/j.immuni.2016.10.010",

language = "English",

volume = "45",

pages = "719--736",

journal = "Immunity",

issn = "1074-7613",

number = "4",

}

TY - JOUR

T1 - Functions of Murine Dendritic Cells

AU - Durai, Vivek

AU - Murphy, Kenneth M.

PY - 2016/10/18

Y1 - 2016/10/18

N2 - Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating adaptive immune responses. The functions of DCs were originally obscured by their overlap with other mononuclear phagocytes, but new mouse models have allowed for the selective ablation of subsets of DCs and have helped to identify their non-redundant roles in the immune system. These tools have elucidated the functions of DCs in host defense against pathogens, autoimmunity, and cancer. This review will describe the mouse models generated to interrogate the role of DCs and will discuss how their use has progressively clarified our understanding of the unique functions of DC subsets.

AB - Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating adaptive immune responses. The functions of DCs were originally obscured by their overlap with other mononuclear phagocytes, but new mouse models have allowed for the selective ablation of subsets of DCs and have helped to identify their non-redundant roles in the immune system. These tools have elucidated the functions of DCs in host defense against pathogens, autoimmunity, and cancer. This review will describe the mouse models generated to interrogate the role of DCs and will discuss how their use has progressively clarified our understanding of the unique functions of DC subsets.

UR - http://www.scopus.com/inward/record.url?scp=84994802422&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2016.10.010

DO - 10.1016/j.immuni.2016.10.010

M3 - Review article

C2 - 27760337

AN - SCOPUS:84994802422

SN - 1074-7613

VL - 45

SP - 719

EP - 736

JO - Immunity

JF - Immunity

IS - 4

ER -

Functions of Murine Dendritic Cells

Abstract

Access to Document

Other files and links

Fingerprint

Cite this