Functionalizable Hydrophilic Polycarbonate, Poly(5-methyl-5-(2-hydroxypropyl)aminocarbonyl-1,3-dioxan-2-one), Designed as a Degradable Alternative for PHPMA and PEG

Sangho Cho, Gyu Seong Heo, Sarosh Khan, Amelia M. Gonzalez, Mahmoud Elsabahy, Karen L. Wooley

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Drawbacks of poly(ethylene glycol) (PEG), the most widely used water-soluble polymer in nanomedicines, have stimulated development of alternative hydrophilic polymers. Among the substitutes, poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) exhibits water solubility, minimal toxicity, and the possibility to introduce functionalities through pendant hydroxyl groups; however, nondegradability may cause long-term health and environmental issues. Alternatively, polycarbonates based on bis-MPA derivatives, which are well-known to be biocompatible, biodegradable, and of low toxicity in vivo, could be utilized as degradable equivalents to polymethacrylates. Therefore, we developed a polycarbonate-based PHPMA analogue, poly(5-methyl-5-(2-hydroxypropyl)aminocarbonyl-1,3-dioxan-2-one) (PMHPAC), by amidation of carboxylic acid-functional polycarbonates with 1-amino-2-propanol. The resulting PMHPAC was highly water-soluble, with low cyto-/immuno-toxicities, and readily functionalizable. These characteristics make PMHPAC a promising candidate as a degradable alternative to PEG and PHPMA. Furthermore, a fully degradable PMHPAC block copolymer was synthesized to demonstrate synthetic versatility and formation of nanostructures in aqueous solution for potential biomedical applications.

Original languageEnglish
Pages (from-to)8797-8805
Number of pages9
JournalMacromolecules
Volume48
Issue number24
DOIs
StatePublished - Dec 22 2015

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