Functional variation in promoter region of Monoamine oxidase A and subtypes of alcoholism: Haplotype analysis

Abbas Parsian, C. Robert Cloninger, Rashmi Sinha, Zhen Hua Zhang

    Research output: Contribution to journalArticle

    27 Scopus citations

    Abstract

    Monoamine oxidase (MAO) is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines. MAO-A, due to its function in central nervous system, has been one of the important candidate genes involved in the development of neuropsychiatric disorders. A functional polymorphism in the promoter region of the MAO-A gene has been identified. This variation affects the transcriptional efficiency of the gene. To determine the role of this MAO-A functional polymorphism in the development of subtypes of alcoholism, a sample of alcoholics and normal controls were screened with this marker. The allele frequency differences between total alcoholics, type I and type II alcoholics, and normal controls was not significance. Comparison of male alcoholics to male normal controls for the frequencies of two-loci and three-loci haplotypes was statistically significant. After Bonferroni's correction for multiple tests none of the results remained significant at P < 0.05. Our results indicate that MAO-A may play a role in the development of alcoholism but the gene effect is very small.

    Original languageEnglish
    Pages (from-to)46-50
    Number of pages5
    JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
    Volume117 B
    Issue number1
    StatePublished - Feb 15 2003

    Keywords

    • Alcoholism
    • Association
    • Functional variation
    • Haplotype
    • Monoamine oxidase A

    Fingerprint Dive into the research topics of 'Functional variation in promoter region of Monoamine oxidase A and subtypes of alcoholism: Haplotype analysis'. Together they form a unique fingerprint.

  • Cite this