Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians

Manasi Mittal, Vaishali Kapoor, Bidhu Kalyan Mohanti, Satya Narayan Das

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We assessed the association of COX-2 polymorphisms at promoter sites -1195, -765 and at 3′UTR (8473) in 193 patients with oral squamous cell carcinoma (OSCC) and 137 normal subjects by PCR-RFLP. Although no significant difference was observed in the frequency of COX-2 -1195G>A, -765G>C and 8473C>T single nucleotide polymorphisms (SNPs) between patients and controls, COX-2 -1195G/A genotype showed higher while -765G/C and 8473C/T showed lower prevalence in patients as compared to normal subjects. Logistic regression analysis of these three polymorphisms revealed a quantitative risk associated with -1195G>A SNP (OR 3.07 at 95%CI) while -765G>C and 8473C>T appeared to be protective. Results of the present study indicate that these three functional variants in the COX-2 regulatory region may contribute to risk modification of tobacco-related oral squamous cell carcinoma in Asian Indians.

Original languageEnglish
Pages (from-to)622-626
Number of pages5
JournalOral Oncology
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Keywords

  • Asian Indians
  • COX-2
  • Oral cancer
  • Single nucleotide polymorphism

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