Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians

Manasi Mittal; Vaishali Kapoor; Bidhu Kalyan Mohanti; Satya Narayan Das

doi:10.1016/j.oraloncology.2010.06.002

Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians

Manasi Mittal, Vaishali Kapoor, Bidhu Kalyan Mohanti, Satya Narayan Das

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We assessed the association of COX-2 polymorphisms at promoter sites -1195, -765 and at 3′UTR (8473) in 193 patients with oral squamous cell carcinoma (OSCC) and 137 normal subjects by PCR-RFLP. Although no significant difference was observed in the frequency of COX-2 -1195G>A, -765G>C and 8473C>T single nucleotide polymorphisms (SNPs) between patients and controls, COX-2 -1195G/A genotype showed higher while -765G/C and 8473C/T showed lower prevalence in patients as compared to normal subjects. Logistic regression analysis of these three polymorphisms revealed a quantitative risk associated with -1195G>A SNP (OR 3.07 at 95%CI) while -765G>C and 8473C>T appeared to be protective. Results of the present study indicate that these three functional variants in the COX-2 regulatory region may contribute to risk modification of tobacco-related oral squamous cell carcinoma in Asian Indians.

Original language	English
Pages (from-to)	622-626
Number of pages	5
Journal	Oral Oncology
Volume	46
Issue number	8
DOIs	https://doi.org/10.1016/j.oraloncology.2010.06.002
State	Published - Aug 2010

Keywords

Asian Indians
COX-2
Oral cancer
Single nucleotide polymorphism

Access to Document

10.1016/j.oraloncology.2010.06.002

Cite this

@article{8f814dc662054e749d2d6e0273b1a256,

title = "Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians",

abstract = "We assessed the association of COX-2 polymorphisms at promoter sites -1195, -765 and at 3′UTR (8473) in 193 patients with oral squamous cell carcinoma (OSCC) and 137 normal subjects by PCR-RFLP. Although no significant difference was observed in the frequency of COX-2 -1195G>A, -765G>C and 8473C>T single nucleotide polymorphisms (SNPs) between patients and controls, COX-2 -1195G/A genotype showed higher while -765G/C and 8473C/T showed lower prevalence in patients as compared to normal subjects. Logistic regression analysis of these three polymorphisms revealed a quantitative risk associated with -1195G>A SNP (OR 3.07 at 95%CI) while -765G>C and 8473C>T appeared to be protective. Results of the present study indicate that these three functional variants in the COX-2 regulatory region may contribute to risk modification of tobacco-related oral squamous cell carcinoma in Asian Indians.",

keywords = "Asian Indians, COX-2, Oral cancer, Single nucleotide polymorphism",

author = "Manasi Mittal and Vaishali Kapoor and Mohanti, {Bidhu Kalyan} and Das, {Satya Narayan}",

note = "Funding Information: This work was partly supported by the Department of Biotechnology (DBT), under BTIS program. M.M. was a recipient of studentship from DBT, Ministry of Science & Technology, Government of India, New Delhi.",

year = "2010",

month = aug,

doi = "10.1016/j.oraloncology.2010.06.002",

language = "English",

volume = "46",

pages = "622--626",

journal = "Oral Oncology",

issn = "1368-8375",

number = "8",

}

TY - JOUR

T1 - Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians

AU - Mittal, Manasi

AU - Kapoor, Vaishali

AU - Mohanti, Bidhu Kalyan

AU - Das, Satya Narayan

N1 - Funding Information: This work was partly supported by the Department of Biotechnology (DBT), under BTIS program. M.M. was a recipient of studentship from DBT, Ministry of Science & Technology, Government of India, New Delhi.

PY - 2010/8

Y1 - 2010/8

N2 - We assessed the association of COX-2 polymorphisms at promoter sites -1195, -765 and at 3′UTR (8473) in 193 patients with oral squamous cell carcinoma (OSCC) and 137 normal subjects by PCR-RFLP. Although no significant difference was observed in the frequency of COX-2 -1195G>A, -765G>C and 8473C>T single nucleotide polymorphisms (SNPs) between patients and controls, COX-2 -1195G/A genotype showed higher while -765G/C and 8473C/T showed lower prevalence in patients as compared to normal subjects. Logistic regression analysis of these three polymorphisms revealed a quantitative risk associated with -1195G>A SNP (OR 3.07 at 95%CI) while -765G>C and 8473C>T appeared to be protective. Results of the present study indicate that these three functional variants in the COX-2 regulatory region may contribute to risk modification of tobacco-related oral squamous cell carcinoma in Asian Indians.

AB - We assessed the association of COX-2 polymorphisms at promoter sites -1195, -765 and at 3′UTR (8473) in 193 patients with oral squamous cell carcinoma (OSCC) and 137 normal subjects by PCR-RFLP. Although no significant difference was observed in the frequency of COX-2 -1195G>A, -765G>C and 8473C>T single nucleotide polymorphisms (SNPs) between patients and controls, COX-2 -1195G/A genotype showed higher while -765G/C and 8473C/T showed lower prevalence in patients as compared to normal subjects. Logistic regression analysis of these three polymorphisms revealed a quantitative risk associated with -1195G>A SNP (OR 3.07 at 95%CI) while -765G>C and 8473C>T appeared to be protective. Results of the present study indicate that these three functional variants in the COX-2 regulatory region may contribute to risk modification of tobacco-related oral squamous cell carcinoma in Asian Indians.

KW - Asian Indians

KW - COX-2

KW - Oral cancer

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=77955509567&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2010.06.002

DO - 10.1016/j.oraloncology.2010.06.002

M3 - Article

C2 - 20620096

AN - SCOPUS:77955509567

SN - 1368-8375

VL - 46

SP - 622

EP - 626

JO - Oral Oncology

JF - Oral Oncology

IS - 8

ER -

Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this