Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

Eynav Klechevsky, Rimpei Morita, Maochang Liu, Yanying Cao, Sebastien Coquery, Lu Ann Thompson-Snipes, Francine Briere, Damien Chaussabel, Gerard Zurawski, A. Karolina Palucka, Yoram Reiter, Jacques Banchereau, Hideki Ueno

Research output: Contribution to journalArticle

425 Scopus citations

Abstract

Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207+ Langerhans cells (LCs) and dermal CD14+ DCs. We showed that CD14+ DCs primed CD4+ T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4+ T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8+ T cells. A third DC population, CD14-CD207-CD1a+ DC, which resides in the dermis, could activate CD8+ T cells better than CD14+ DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14+ DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.

Original languageEnglish
Pages (from-to)497-510
Number of pages14
JournalImmunity
Volume29
Issue number3
DOIs
StatePublished - Sep 19 2008
Externally publishedYes

Keywords

  • CELLIMMUNO

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    Klechevsky, E., Morita, R., Liu, M., Cao, Y., Coquery, S., Thompson-Snipes, L. A., Briere, F., Chaussabel, D., Zurawski, G., Palucka, A. K., Reiter, Y., Banchereau, J., & Ueno, H. (2008). Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells. Immunity, 29(3), 497-510. https://doi.org/10.1016/j.immuni.2008.07.013