Functional significance of S6K overexpression in meningioma progression

Ezequiel I. Surace, Eriks Lusis, Carrie A. Haipek, David H. Gutmann

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

One common genetic change in anaplastic meningiomas is amplification of chromosome 17q23 containing the S6 kinase (S6K) gene. We show, for the first time to our knowledge, increased S6K mRNA expression in anaplastic meningiomas compared with benign tumors. To evaluate S6K as a candidate meningioma progression gene, we generated IOMM-Lee human meningioma cell lines overexpressing S6K. Whereas no effect of S6K overexpression on meningioma cell growth, motility, or adhesion was observed in vitro, S6K overexpression resulted in increased tumor size in vivo. Collectively, these results suggest that S6K is functionally important for meningioma progression and may represent a target for future meningioma therapy.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalAnnals of neurology
Volume56
Issue number2
DOIs
StatePublished - Aug 2004

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