Functional significance of S6K overexpression in meningioma progression

Ezequiel I. Surace; Eriks Lusis; Carrie A. Haipek; David H. Gutmann

doi:10.1002/ana.20201

Functional significance of S6K overexpression in meningioma progression

Ezequiel I. Surace, Eriks Lusis, Carrie A. Haipek, David H. Gutmann

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32 Scopus citations

Abstract

One common genetic change in anaplastic meningiomas is amplification of chromosome 17q23 containing the S6 kinase (S6K) gene. We show, for the first time to our knowledge, increased S6K mRNA expression in anaplastic meningiomas compared with benign tumors. To evaluate S6K as a candidate meningioma progression gene, we generated IOMM-Lee human meningioma cell lines overexpressing S6K. Whereas no effect of S6K overexpression on meningioma cell growth, motility, or adhesion was observed in vitro, S6K overexpression resulted in increased tumor size in vivo. Collectively, these results suggest that S6K is functionally important for meningioma progression and may represent a target for future meningioma therapy.

Original language	English
Pages (from-to)	295-298
Number of pages	4
Journal	Annals of neurology
Volume	56
Issue number	2
DOIs	https://doi.org/10.1002/ana.20201
State	Published - Aug 2004

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title = "Functional significance of S6K overexpression in meningioma progression",

abstract = "One common genetic change in anaplastic meningiomas is amplification of chromosome 17q23 containing the S6 kinase (S6K) gene. We show, for the first time to our knowledge, increased S6K mRNA expression in anaplastic meningiomas compared with benign tumors. To evaluate S6K as a candidate meningioma progression gene, we generated IOMM-Lee human meningioma cell lines overexpressing S6K. Whereas no effect of S6K overexpression on meningioma cell growth, motility, or adhesion was observed in vitro, S6K overexpression resulted in increased tumor size in vivo. Collectively, these results suggest that S6K is functionally important for meningioma progression and may represent a target for future meningioma therapy.",

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AU - Lusis, Eriks

AU - Haipek, Carrie A.

AU - Gutmann, David H.

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AB - One common genetic change in anaplastic meningiomas is amplification of chromosome 17q23 containing the S6 kinase (S6K) gene. We show, for the first time to our knowledge, increased S6K mRNA expression in anaplastic meningiomas compared with benign tumors. To evaluate S6K as a candidate meningioma progression gene, we generated IOMM-Lee human meningioma cell lines overexpressing S6K. Whereas no effect of S6K overexpression on meningioma cell growth, motility, or adhesion was observed in vitro, S6K overexpression resulted in increased tumor size in vivo. Collectively, these results suggest that S6K is functionally important for meningioma progression and may represent a target for future meningioma therapy.

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Functional significance of S6K overexpression in meningioma progression

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