TY - JOUR
T1 - Functional quality of life among newly diagnosed young adult colorectal cancer survivors compared to older adults
T2 - results from the ColoCare Study
AU - Oswald, Laura B.
AU - Bloomer, Amanda
AU - Li, Xiaoyin
AU - Jean-Baptiste, Esther
AU - Trujillo, Gillian
AU - Felder, Seth
AU - Small, Brent J.
AU - Ose, Jennifer
AU - Hardikar, Sheetal
AU - Strehli, Ildiko
AU - Huang, Lyen C.
AU - Mooney, Kathi
AU - Mutch, Matthew G.
AU - Chao, Dante
AU - Cohen, Stacey A.
AU - Karchi, Meghana
AU - Wood, Elizabeth H.
AU - Damerell, Victoria
AU - Loroña, Nicole C.
AU - Gong, Jun
AU - Toriola, Adetunji T.
AU - Li, Christopher I.
AU - Shibata, David
AU - Schneider, Martin
AU - Gigic, Biljana
AU - Figueiredo, Jane C.
AU - Jim, Heather S.L.
AU - Ulrich, Cornelia M.
AU - Siegel, Erin M.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Purpose: Colorectal cancer (CRC) incidence and mortality are increasing among young adults (YAs) aged 18–39. This study compared quality of life (QOL) between YA and older adult CRC survivors in the ColoCare Study. Methods: Participants were grouped by age (years) as follows: 18–39 (YA), 40–49, 50–64, and 65 +. Functional QOL (physical, social, role, emotional, cognitive) and global QOL were assessed with the EORTC-QLQ-C30 at enrollment, 3, 6, and 12 months. Average scores were compared between groups over time using longitudinal mixed-effect modeling. Proportions with clinically meaningful QOL impairment were calculated using age-relevant thresholds and compared between groups over time using logistic regression with mixed effects. Results: Participants (N = 1590) were n = 81 YAs, n = 196 aged 40–49, n = 627 aged 50–64, and n = 686 aged 65 +. Average physical function was better among YAs than participants aged 50–64 (p = 0.010) and 65 + (p < 0.001), and average social function was worse among YAs than aged 65 + (p = 0.046). Relative to YAs, all age groups were less likely to report clinically meaningful social dysfunction (aged 40–49 OR = 0.13, 95%CI = 0.06–0.29; aged 50–64 OR = 0.10, 95%CI = 0.05–0.21; aged 65 + OR = 0.07, 95%CI = 0.04–0.15) and role dysfunction (aged 40–49 OR = 0.36, 95%CI = 0.18–0.75; aged 50–64 OR = 0.41, 95%CI = 0.22–0.78; aged 65 + OR = 0.32, 95%CI = 0.17–0.61). Participants aged 40–49 were also less likely to report physical dysfunction (OR = 0.42, 95%CI = 0.19–0.93). Conclusion: YA CRC survivors reported better physical and worse social function compared to older CRC survivors, and YA CRC survivors were more likely to report clinically meaningful social, role, and physical disfunction. Future work should further investigate QOL using age-relevant benchmarks to inform best practices for CRC survivorship care. Trial registration: NCT02328677, registered December 2014.
AB - Purpose: Colorectal cancer (CRC) incidence and mortality are increasing among young adults (YAs) aged 18–39. This study compared quality of life (QOL) between YA and older adult CRC survivors in the ColoCare Study. Methods: Participants were grouped by age (years) as follows: 18–39 (YA), 40–49, 50–64, and 65 +. Functional QOL (physical, social, role, emotional, cognitive) and global QOL were assessed with the EORTC-QLQ-C30 at enrollment, 3, 6, and 12 months. Average scores were compared between groups over time using longitudinal mixed-effect modeling. Proportions with clinically meaningful QOL impairment were calculated using age-relevant thresholds and compared between groups over time using logistic regression with mixed effects. Results: Participants (N = 1590) were n = 81 YAs, n = 196 aged 40–49, n = 627 aged 50–64, and n = 686 aged 65 +. Average physical function was better among YAs than participants aged 50–64 (p = 0.010) and 65 + (p < 0.001), and average social function was worse among YAs than aged 65 + (p = 0.046). Relative to YAs, all age groups were less likely to report clinically meaningful social dysfunction (aged 40–49 OR = 0.13, 95%CI = 0.06–0.29; aged 50–64 OR = 0.10, 95%CI = 0.05–0.21; aged 65 + OR = 0.07, 95%CI = 0.04–0.15) and role dysfunction (aged 40–49 OR = 0.36, 95%CI = 0.18–0.75; aged 50–64 OR = 0.41, 95%CI = 0.22–0.78; aged 65 + OR = 0.32, 95%CI = 0.17–0.61). Participants aged 40–49 were also less likely to report physical dysfunction (OR = 0.42, 95%CI = 0.19–0.93). Conclusion: YA CRC survivors reported better physical and worse social function compared to older CRC survivors, and YA CRC survivors were more likely to report clinically meaningful social, role, and physical disfunction. Future work should further investigate QOL using age-relevant benchmarks to inform best practices for CRC survivorship care. Trial registration: NCT02328677, registered December 2014.
KW - Cancer survivors
KW - Colorectal cancer
KW - Patient-reported outcomes
KW - Quality of life
KW - Young adult
UR - http://www.scopus.com/inward/record.url?scp=85190806902&partnerID=8YFLogxK
U2 - 10.1007/s00520-024-08511-5
DO - 10.1007/s00520-024-08511-5
M3 - Article
C2 - 38639810
AN - SCOPUS:85190806902
SN - 0941-4355
VL - 32
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 5
M1 - 298
ER -