Functional mapping of the human visual cortex by magnetic resonance imaging

J. W. Belliveau, D. N. Kennedy, R. C. McKinstry, B. R. Buchbinder, R. M. Weisskoff, M. S. Cohen, J. M. Vevea, T. J. Brady, B. R. Rosen

Research output: Contribution to journalArticlepeer-review

1365 Scopus citations

Abstract

Knowledge of regional cerebral hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelation between physiological function, energy metabolism, and localized blood supply. A magnetic resonance technique was developed for quantitative imaging of cerebral hemodynamics, allowing for measurement of regional cerebral blood volume during resting and activated cognitive states. This technique was used to generate the first functional magnetic resonance maps of human task activation, by using a visual stimulus paradigm. During photic stimulation, localized increases in blood volume (32 ± 10 percent, n = 7 subjects) were detected in the primary visual cortex. Center-of-mass coordinates and linear extents of brain activation within the plane of the calcarine fissure are reported.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalScience
Volume254
Issue number5032
DOIs
StatePublished - 1991

Fingerprint

Dive into the research topics of 'Functional mapping of the human visual cortex by magnetic resonance imaging'. Together they form a unique fingerprint.

Cite this