@article{f91fca0db4644330a64d217323226602,
title = "Functional Implications of Intracellular Phase Transitions",
abstract = "Intracellular environments are heterogeneous milieus comprised of macromolecules, osmolytes, and a range of assemblies that include membrane-bound organelles and membraneless biomolecular condensates. The latter are nonstoichiometric assemblies of protein and RNA molecules. They represent distinct phases and form via intracellular phase transitions. Here, we present insights from recent studies and provide a perspective on how phase transitions that lead to biomolecular condensates might contribute to cellular functions.",
author = "Holehouse, {Alex S.} and Pappu, {Rohit V.}",
note = "Funding Information: The National Science Foundation (MCB1614766), the National Institutes of Health (5R01NS056114), the Human Frontier Science Program (RGP0034/2017) and the research collaborative on membraneless organelles sponsored by St. Jude Children's Research Hospital have supported our work. Funding Information: *E-mail: alex.holehouse@wustl.edu. *E-mail: pappu@wustl.edu. ORCID Alex S. Holehouse: 0000-0002-4155-5729 Rohit V. Pappu: 0000-0003-2568-1378 Funding The National Science Foundation (MCB1614766), the National Institutes of Health (5R01NS056114), the Human Frontier Science Program (RGP0034/2017), and the research collaborative on membraneless organelles sponsored by St. Jude Children{\textquoteright}s Research Hospital have supported our work. Notes The authors declare no competing financial interest. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = may,
day = "1",
doi = "10.1021/acs.biochem.7b01136",
language = "English",
volume = "57",
pages = "2415--2423",
journal = "Biochemistry",
issn = "0006-2960",
number = "17",
}