Functional Implications of Intracellular Phase Transitions

Alex S. Holehouse, Rohit V. Pappu

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Intracellular environments are heterogeneous milieus comprised of macromolecules, osmolytes, and a range of assemblies that include membrane-bound organelles and membraneless biomolecular condensates. The latter are nonstoichiometric assemblies of protein and RNA molecules. They represent distinct phases and form via intracellular phase transitions. Here, we present insights from recent studies and provide a perspective on how phase transitions that lead to biomolecular condensates might contribute to cellular functions.

Original languageEnglish
Pages (from-to)2415-2423
Number of pages9
Issue number17
StatePublished - May 1 2018


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