TY - JOUR
T1 - Functional heterogeneity in the memory B-cell response
AU - Henry, Brittany
AU - Laidlaw, Brian J.
N1 - Funding Information:
The Laidlaw laboratory is supported by National Institute of Allergy and Infectious Diseases (NIAID, USA) grants DP2AI169978 and K22AI153015. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIAID or NIH. Figures created using Biorender.
Funding Information:
The Laidlaw laboratory is supported by National Institute of Allergy and Infectious Diseases (NIAID, USA) grants DP2AI169978 and K22AI153015 . The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIAID or NIH. Figures created using Biorender.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2023/2
Y1 - 2023/2
N2 - Most vaccines induce robust antibody and memory B-cell (MBC) responses that are capable of mediating protective immunity. However, antibody titers wane following vaccination necessitating the administration of booster vaccines to maintain a protective antibody titer. MBCs are stably maintained following vaccination and can rapidly give rise to antibody-secreting cells or undergo further affinity maturation upon antigen re-encounter. Repeated antigen encounter results in the development of MBCs that encode antibodies capable of mediating broadly protective immunity against viruses such as SARS-CoV-2 and influenza. Here, we summarize emerging evidence that MBCs are a heterogeneous population composed of transcriptionally and phenotypically distinct subsets that have discrete roles in mediating protective immunity upon antigen re-encounter and examine the implications of these findings for the development of vaccines capable of eliciting broadly protective immunity.
AB - Most vaccines induce robust antibody and memory B-cell (MBC) responses that are capable of mediating protective immunity. However, antibody titers wane following vaccination necessitating the administration of booster vaccines to maintain a protective antibody titer. MBCs are stably maintained following vaccination and can rapidly give rise to antibody-secreting cells or undergo further affinity maturation upon antigen re-encounter. Repeated antigen encounter results in the development of MBCs that encode antibodies capable of mediating broadly protective immunity against viruses such as SARS-CoV-2 and influenza. Here, we summarize emerging evidence that MBCs are a heterogeneous population composed of transcriptionally and phenotypically distinct subsets that have discrete roles in mediating protective immunity upon antigen re-encounter and examine the implications of these findings for the development of vaccines capable of eliciting broadly protective immunity.
UR - http://www.scopus.com/inward/record.url?scp=85146450654&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2022.102281
DO - 10.1016/j.coi.2022.102281
M3 - Review article
C2 - 36652774
AN - SCOPUS:85146450654
SN - 0952-7915
VL - 80
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
M1 - 102281
ER -