Functional group I metabotropic glutamate receptors in submucous plexus of guinea-pig ileum

Hong Zhen Hu, Jun Ren, Sumei Liu, Chuanyun Gao, Yun Xia, Jackie D. Wood

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Intracellular recording methods and immunostaining revealed the existence of functional group I metabotropic glutamate receptors (mGluRs) in submucous plexus neurons of guinea-pig ileum. Selective group I, but not groups II or III metabotropic glutamate receptor agonists induced concentration-dependent, slowly-activating depolarizing responses. Group I metabotropic glutamate receptor antagonism observed with (S)-4-carboxyphenylglycine (S-4-CPG) (100-600 μM) was competitive as determined by Schild analysis (pA2 = 3.81 ± 0.02). Neither the group II and III metabotropic nor ionotropic glutamate receptor antagonists altered responses evoked by group I receptor agonists. Immunoreactivities for metabotropic glutamate 1α and 5 receptors were found to locate exclusively in neurons in the submucous plexus of guinea-pig ileum with the highest density around the cell bodies. The results suggest that group I metabotropic glutamate receptors are functionally expressed in the submucous plexus of guinea-pig small intestine.

Original languageEnglish
Pages (from-to)1631-1635
Number of pages5
JournalBritish Journal of Pharmacology
Volume128
Issue number8
DOIs
StatePublished - 1999

Keywords

  • Enteric nervous system
  • Intestinal secretion
  • Metabotropic glutamate receptors
  • Small intestine
  • Submucous plexus

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