Functional genomics approach identifies novel signaling regulators of TGFα ectodomain shedding

Keyphrases

• ADAM17 33%
• Bypass Signaling 33%
• Cancer Cell Growth 33%
• Cancer Cells 33%
• Cancer Development 33%
• Cancer Growth 33%
• Cancer Metastasis 33%
• Cancer Therapeutics 33%
• Cell Surface 33%
• Computational Network Analysis 33%
• Disintegrin 33%
• Ectodomain Cleavage 33%
• Ectodomain Shedding 100%
• EGFR Inhibition 33%
• EGFR Ligands 100%
• EGFR Transactivation 33%
• Functional Genomics 100%
• Genetic Screening 66%
• Genome-scale Networks 33%
• Genomic Approaches 100%
• Growth Factor Pathway 33%
• Growth Factors 33%
• In Cancer 33%
• Inflammation 33%
• Inflammatory Regulators 33%
• Ligand Release 33%
• Ligand Shedding 33%
• Mechanistic Understanding 33%
• Metalloprotease 100%
• Network Analysis 33%
• Novel Regulator 33%
• Outcompete 33%
• Precursor Protein 33%
• Regulatory Function 66%
• Screening Analysis 33%
• Short Hairpin RNA (shRNA) 33%
• Signaling Pathway 33%
• Test Validity 33%
• Treatment Opportunity 33%

Biochemistry, Genetics and Molecular Biology

• ADAM17 14%
• Cancer Cell 28%
• Cell Growth 14%
• Disintegrin 14%
• Ectodomain 100%
• Epidermal Growth Factor Receptor 100%
• Functional Genomics 100%
• Genomics 28%
• Growth Factor 14%
• Growth, Development and Aging 14%
• Metalloendopeptidase 28%
• Metalloproteinase 14%
• Protein Precursor 14%
• Signal Transduction 14%
• Small Hairpin RNA 14%