The Regulators of Complement Activation (RCA) are a fascinating group of proteins that play important roles in innate and acquired immunity. In this review, we examine structure-function aspects of three membrane-bound RCA proteins and discuss the unique impact of their genetic organization on their evolution. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)103-116
Number of pages14
Issue number1-2
StatePublished - 2000


  • CR1 (CD35), MCP (CD46) and DAF (CD55)
  • Complement regulatory proteins
  • Functional domains of CR1, MCP, DAF
  • Pathogen interactions with CR1, MCP, DAF
  • Regulators of complement (RCA) genes/proteins
  • Structural variations in mammals of CR1, MCP, DAF


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