Functional diversity of helper T lymphocytes

Abul K. Abbas, Kenneth M. Murphy, Alan Sher

Research output: Contribution to journalReview article

3699 Scopus citations

Abstract

The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.

Original languageEnglish
Pages (from-to)787-793
Number of pages7
JournalNature
Volume383
Issue number6603
DOIs
StatePublished - Oct 31 1996

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