Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

Keyphrases

• Protein Kinase 100%
• Amino Acid Residues 100%
• Domain Structure 100%
• Cdc37 100%
• Functional Dissection 100%
• Heat Shock Protein 90 (Hsp90) 60%
• Recombinant 6%
• Mass Spectrometry Analysis 6%
• Mutagenesis 6%
• Functional Assay 6%
• Peptide Fragments 6%
• N-terminus 6%
• N-terminal Domain 6%
• Structure Function 6%
• High-affinity Binding 6%
• Binding Activity 6%
• Heme 6%
• Co-chaperone 6%
• MALDI-TOF Mass Spectrometry 6%
• Allosteric Interactions 6%
• EIF2α Kinase 6%
• Interpreter 6%
• Limited Proteolysis 6%
• Middle Domain 6%
• Discrete Domain 6%

Biochemistry, Genetics and Molecular Biology

• Protein Kinases 100%
• Amino Acids 100%
• Hsp90 100%
• Kinase 55%
• Phosphotransferase 55%
• N-Terminus 22%
• Binding Affinity 22%
• Conformation 22%
• C-Terminus 11%
• Mutagenesis 11%
• Structure Activity Relation 11%
• Mass Spectrometry 11%
• Matrix-Assisted Laser Desorption-Ionization 11%
• Co-Chaperone 11%
• Alanine 11%
• Proteolysis 11%