Functional Connectivity of the Striatum in Schizophrenia and Psychotic Bipolar Disorder

Nicole R. Karcher, Baxter P. Rogers, Neil D. Woodward

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: The striatum is abnormal in schizophrenia and possibly represents a common neurobiological mechanism underlying psychotic disorders. Resting-state functional magnetic resonance imaging studies have not reached a consensus regarding striatal dysconnectivity in schizophrenia, although these studies generally find impaired frontoparietal and salience network connectivity. The goal of the current study was to clarify the pattern of corticostriatal connectivity, including whether corticostriatal dysconnectivity is transdiagnostic and extends into psychotic bipolar disorder. Methods: We examined corticostriatal functional connectivity in 60 healthy subjects and 117 individuals with psychosis, including 77 with a schizophrenia spectrum illness and 40 with psychotic bipolar disorder. We conducted a cortical seed–based region-of-interest analysis with follow-up voxelwise analysis for any significant results. Further, a striatum seed–based analysis was conducted to examine group differences in connectivity between the striatum and the whole cortex. Results: Cortical region-of-interest analysis indicated that overall connectivity of the salience network with the striatum was reduced in psychotic disorders, which follow-up voxelwise analysis localized to the left putamen. Striatum seed–based analyses showed reduced ventral rostral putamen connectivity with the salience network portion of the medial prefrontal cortex in both schizophrenia and psychotic bipolar disorder. Conclusions: The current study found evidence of transdiagnostic corticostriatal dysconnectivity in both schizophrenia and psychotic bipolar disorder, including reduced salience network connectivity, as well as reduced connectivity between the putamen and the medial prefrontal cortex. Overall, the current study points to the relative importance of salience network hypoconnectivity in psychotic disorders.

Original languageEnglish
Pages (from-to)956-965
Number of pages10
JournalBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Issue number11
StatePublished - Nov 2019


  • Cortex
  • Psychosis
  • Psychotic bipolar disorder
  • Resting-state fMRI
  • Schizophrenia
  • Striatum


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