Functional connectivity of the amygdala in early-childhood-onset depression

Katherine R. Luking, Grega Repovs, Andy C. Belden, Michael S. Gaffrey, Kelly N. Botteron, Joan L. Luby, Deanna M. Barch

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Objective: Adult major depressive disorder (MDD) is associated with reduced cortico-limbic functional connectivity thought to indicate decreased top-down control of emotion. However, it is unclear whether such connectivity alterations are also present in early-childhoodonset MDD. Method: A total of 51 children 7 through 11 years of age who had been prospectively studied since preschool age, completed resting state functional magnetic resonance imaging (fMRI) and were assigned to one of four groups: 1) C-MDD (N = 13), those children with a personal history of early-childhoodonset MDD; 2) M-MDD (N = 11), those with a maternal history of affective disorders; 3) CM-MDD (N = 13), those with both maternal and early-childhoodonset MDD; or 4) CON (N = 14), those without either a personal or maternal history of MDD. We used seed-based resting state functional connectivity (rsfcMRI) analysis in an independent sample of adults to identify networks showing both positive (e.g., limbic regions) and negative (e.g., dorsal frontal/parietal regions) connectivity with the amygdala. These regions were then used in region-of-interestbased analyses of our child sample. Results: We found a significant interaction between maternal affective disorder history and the child's MDD history for both positive and negative rsfcMRI networks. Specifically, when compared with CON, we found reduced connectivity between the amygdala and the "negative network" in children with C-MDD, M-MDD, and CM-MDD. Children with either C-MDD or a maternal history of MDD (but not CM-MDD) displayed reduced connectivity between the amygdala and the "positive network." Conclusions: Our finding of an attenuated relationship between the amygdala, a region affected in MDD and involved in emotion processing, and cognitive control regions is consistent with a hypothesis of altered regulation of emotional processing in C-MDD, suggesting developmental continuity of this alteration into early childhood.

Original languageEnglish
Pages (from-to)1027-1041.e3
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume50
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • amygdala
  • childhood-onset
  • depression
  • fMRI
  • functional connectivity

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