Functional connectivity arises from a slow rhythmic mechanism

Jingfeng M. Li; William J. Bentley; Abraham Z. Snyder; Marcus E. Raichle; Lawrence H. Snyder

doi:10.1073/pnas.1419837112

Functional connectivity arises from a slow rhythmic mechanism

Jingfeng M. Li, William J. Bentley, Abraham Z. Snyder, Marcus E. Raichle, Lawrence H. Snyder

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47 Scopus citations

Abstract

The mechanism underlying temporal correlations among blood oxygen level-dependent signals is unclear. We used oxygen polarography to better characterize oxygen fluctuations and their correlation and to gain insight into the driving mechanism. The power spectrum of local oxygen fluctuations is inversely proportional to frequency raised to a power (1/f) raised to the beta, with an additional positive band-limited component centered at 0.06 Hz. In contrast, the power of the correlated oxygen signal is band limited from ∼.01 Hz to 0.4 Hz with a peak at 0.06 Hz. These results suggest that there is a band-limited mechanism (or mechanisms) driving interregional oxygen correlation that is distinct from the mechanism(s) driving local (1/f) oxygen fluctuations. Candidates for driving interregional oxygen correlation include rhythmic or pseudo-oscillatory mechanisms.

Original language	English
Pages (from-to)	E2527-E2535
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	112
Issue number	19
DOIs	https://doi.org/10.1073/pnas.1419837112
State	Published - May 12 2015

Keywords

Band-limited
Criticality
Oscillation
Oxygen polarography
Resting-state functional connectivity

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10.1073/pnas.1419837112

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abstract = "The mechanism underlying temporal correlations among blood oxygen level-dependent signals is unclear. We used oxygen polarography to better characterize oxygen fluctuations and their correlation and to gain insight into the driving mechanism. The power spectrum of local oxygen fluctuations is inversely proportional to frequency raised to a power (1/f) raised to the beta, with an additional positive band-limited component centered at 0.06 Hz. In contrast, the power of the correlated oxygen signal is band limited from ∼.01 Hz to 0.4 Hz with a peak at 0.06 Hz. These results suggest that there is a band-limited mechanism (or mechanisms) driving interregional oxygen correlation that is distinct from the mechanism(s) driving local (1/f) oxygen fluctuations. Candidates for driving interregional oxygen correlation include rhythmic or pseudo-oscillatory mechanisms.",

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AU - Li, Jingfeng M.

AU - Bentley, William J.

AU - Snyder, Abraham Z.

AU - Raichle, Marcus E.

AU - Snyder, Lawrence H.

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Functional connectivity arises from a slow rhythmic mechanism

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