Functional connectivity arises from a slow rhythmic mechanism

Jingfeng M. Li, William J. Bentley, Abraham Z. Snyder, Marcus E. Raichle, Lawrence H. Snyder

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The mechanism underlying temporal correlations among blood oxygen level-dependent signals is unclear. We used oxygen polarography to better characterize oxygen fluctuations and their correlation and to gain insight into the driving mechanism. The power spectrum of local oxygen fluctuations is inversely proportional to frequency raised to a power (1/f) raised to the beta, with an additional positive band-limited component centered at 0.06 Hz. In contrast, the power of the correlated oxygen signal is band limited from ∼.01 Hz to 0.4 Hz with a peak at 0.06 Hz. These results suggest that there is a band-limited mechanism (or mechanisms) driving interregional oxygen correlation that is distinct from the mechanism(s) driving local (1/f) oxygen fluctuations. Candidates for driving interregional oxygen correlation include rhythmic or pseudo-oscillatory mechanisms.

Original languageEnglish
Pages (from-to)E2527-E2535
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number19
DOIs
StatePublished - May 12 2015

Keywords

  • Band-limited
  • Criticality
  • Oscillation
  • Oxygen polarography
  • Resting-state functional connectivity

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