Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor

Keyphrases

• ATP-binding Cassette Transporter A1 (ABCA1) 50%
• Channel Activity 16%
• Channel Regulation 16%
• Channel Subunits 16%
• Cysteine Modification 16%
• D-loop 16%
• Dimer Interface 100%
• Engineered Cysteine 16%
• Functional Clustering 100%
• Functional Impact 16%
• Gain-of-function mutation 16%
• Hyperstimulation 16%
• Intact Cells 16%
• K Channels 16%
• KATP Channel 33%
• Kir6.1 16%
• Kir6.2 16%
• Mutagenesis 16%
• Mutation Cluster 16%
• Nucleotide Binding 100%
• Nucleotides Interaction 16%
• Pore-forming 16%
• Receptor Subunits 33%
• SUR1 100%

Pharmacology, Toxicology and Pharmaceutical Science

• ABC Transporter 75%
• Adenosine Triphosphate 50%
• Adenosine Triphosphate Sensitive Potassium Channel 50%
• Cysteine 25%
• Dimer 100%
• Heterodimer 75%
• Mutagenesis 25%
• Potassium Channel 25%
• Potassium Ion 25%
• Receptor Subunit 50%
• Sulfonylurea Receptor 100%

Biochemistry, Genetics and Molecular Biology

• ABC Transporter 75%
• Adenosine Triphosphate 50%
• Adenosine Triphosphate Sensitive Potassium Channel 50%
• ATP-binding Cassette Transporter 25%
• Crystal Structure 25%
• Cysteine 25%
• D-Loop 25%
• Gain of Function Mutation 25%
• Kir6.2 25%
• Mutagenesis 25%
• Potassium Channel 25%
• Sulfonylurea Receptor 100%