Functional characterization of the dural sinuses as a neuroimmune interface

Justin Rustenhoven, Antoine Drieu, Tornike Mamuladze, Kalil Alves de Lima, Taitea Dykstra, Morgan Wall, Zachary Papadopoulos, Mitsuhiro Kanamori, Andrea Francesca Salvador, Wendy Baker, Mackenzie Lemieux, Sandro Da Mesquita, Andrea Cugurra, James Fitzpatrick, Sanja Sviben, Ross Kossina, Peter Bayguinov, Reid R. Townsend, Qiang Zhang, Petra Erdmann-GilmoreIgor Smirnov, Maria Beatriz Lopes, Jasmin Herz, Jonathan Kipnis

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune interactions play an active role in diverse neurological disorders. However, the precise mechanisms underlying CNS immune surveillance remain elusive; particularly, the anatomical sites where peripheral adaptive immunity can sample CNS-derived antigens and the cellular and molecular mediators orchestrating this surveillance. Here, we demonstrate that CNS-derived antigens in the cerebrospinal fluid (CSF) accumulate around the dural sinuses, are captured by local antigen-presenting cells, and are presented to patrolling T cells. This surveillance is enabled by endothelial and mural cells forming the sinus stromal niche. T cell recognition of CSF-derived antigens at this site promoted tissue resident phenotypes and effector functions within the dural meninges. These findings highlight the critical role of dural sinuses as a neuroimmune interface, where brain antigens are surveyed under steady-state conditions, and shed light on age-related dysfunction and neuroinflammatory attack in animal models of multiple sclerosis.

Original languageEnglish
Pages (from-to)1000-1016.e27
JournalCell
Volume184
Issue number4
DOIs
StatePublished - Feb 18 2021

Keywords

  • antigen presentation
  • CNS autoimmunity
  • CSF flow
  • dura mater
  • meningeal immunity
  • meningeal lymphatics
  • meninges
  • neuroimmunology
  • sinus
  • stromal cells

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