Functional cerebral imaging by susceptibility‐contrast NMR

John W. Belliveau; Bruce R. Rosen; Howard L. Kantor; Richard R. Rzedzian; David N. Kennedy; Robert C. McKinstry; James M. Vevea; Mark S. Cohen; Ian L. Pykett; Thomas J. Brady

doi:10.1002/mrm.1910140311

Functional cerebral imaging by susceptibility‐contrast NMR

John W. Belliveau, Bruce R. Rosen, Howard L. Kantor, Richard R. Rzedzian, David N. Kennedy, Robert C. McKinstry, James M. Vevea, Mark S. Cohen, Ian L. Pykett, Thomas J. Brady

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Abstract

In vivo measurement of cerebral physiology by dynamic contrast‐enhanced NMR is demonstrated. Time‐resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility‐induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured. © 1990 Academic Press, Inc.

Original language	English
Pages (from-to)	538-546
Number of pages	9
Journal	Magnetic resonance in medicine
Volume	14
Issue number	3
DOIs	https://doi.org/10.1002/mrm.1910140311
State	Published - Jun 1990

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title = "Functional cerebral imaging by susceptibility‐contrast NMR",

abstract = "In vivo measurement of cerebral physiology by dynamic contrast‐enhanced NMR is demonstrated. Time‐resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility‐induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured. {\textcopyright} 1990 Academic Press, Inc.",

author = "Belliveau, {John W.} and Rosen, {Bruce R.} and Kantor, {Howard L.} and Rzedzian, {Richard R.} and Kennedy, {David N.} and McKinstry, {Robert C.} and Vevea, {James M.} and Cohen, {Mark S.} and Pykett, {Ian L.} and Brady, {Thomas J.}",

year = "1990",

month = jun,

doi = "10.1002/mrm.1910140311",

language = "English",

volume = "14",

pages = "538--546",

journal = "Magnetic resonance in medicine",

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T1 - Functional cerebral imaging by susceptibility‐contrast NMR

AU - Belliveau, John W.

AU - Rosen, Bruce R.

AU - Kantor, Howard L.

AU - Rzedzian, Richard R.

AU - Kennedy, David N.

AU - McKinstry, Robert C.

AU - Vevea, James M.

AU - Cohen, Mark S.

AU - Pykett, Ian L.

AU - Brady, Thomas J.

PY - 1990/6

Y1 - 1990/6

N2 - In vivo measurement of cerebral physiology by dynamic contrast‐enhanced NMR is demonstrated. Time‐resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility‐induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured. © 1990 Academic Press, Inc.

AB - In vivo measurement of cerebral physiology by dynamic contrast‐enhanced NMR is demonstrated. Time‐resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility‐induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured. © 1990 Academic Press, Inc.

UR - http://www.scopus.com/inward/record.url?scp=0024999052&partnerID=8YFLogxK

U2 - 10.1002/mrm.1910140311

DO - 10.1002/mrm.1910140311

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AN - SCOPUS:0024999052

SN - 0740-3194

VL - 14

SP - 538

EP - 546

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

IS - 3

ER -

Functional cerebral imaging by susceptibility‐contrast NMR

Abstract

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