Fullerene-based antioxidants and neurodegenerative disorders

L. L. Dugan, E. G. Lovett, K. L. Quick, J. Lotharius, T. T. Lin, K. L. O'Malley

Research output: Contribution to journalArticle

241 Scopus citations

Abstract

Water-soluble derivatives of buckminsterfullerene (C60) derivatives are a unique class of compounds with potent antioxidant properties. Studies on one class of these compounds, the malonic acid C60 derivatives (carboxyfullerenes), indicated that they are capable of eliminating both superoxide anion and H2O2, and were effective inhibitors of lipid peroxidation, as well. Carboxyfullerenes demonstrated robust neuroprotection against excitotoxic, apoptotic and metabolic insults in cortical cell cultures. They were also capable of rescuing mesencephalic dopaminergic neurons from both MPP+ and 6-hydroxydopamine-induced degeneration. Although there is limited in vivo data on these compounds to date, we have previously reported that systemic administration of the C3 carboxyfullerene isomer delayed motor deterioration and death in a mouse model of familial amyotrophic lateral sclerosis (FALS). Ongoing studies in other animal models of CNS disease states suggest that these novel antioxidants are potential neuroprotective agents for other neurodegenerative disorders, including Parkinson's disease.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalParkinsonism and Related Disorders
Volume7
Issue number3
DOIs
StatePublished - May 7 2001

Keywords

  • Antioxidants
  • Apoptosis
  • Excitotoxicity
  • Parkinson's disease
  • Superoxide

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