TY - JOUR
T1 - Full-field, frequency-domain comparison of simulated and measured human brain deformation
AU - Arani, Amir H.G.
AU - Okamoto, Ruth J.
AU - Escarcega, Jordan D.
AU - Jerusalem, Antoine
AU - Alshareef, Ahmed A.
AU - Bayly, Philip V.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
PY - 2024
Y1 - 2024
N2 - We propose a robust framework for quantitatively comparing model-predicted and experimentally measured strain fields in the human brain during harmonic skull motion. Traumatic brain injuries (TBIs) are typically caused by skull impact or acceleration, but how skull motion leads to brain deformation and consequent neural injury remains unclear and comparison of model predictions to experimental data remains limited. Magnetic resonance elastography (MRE) provides high-resolution, full-field measurements of dynamic brain deformation induced by harmonic skull motion. In the proposed framework, full-field strain measurements from human brain MRE in vivo are compared to simulated strain fields from models with similar harmonic loading. To enable comparison, the model geometry and subject anatomy, and subsequently, the predicted and measured strain fields are nonlinearly registered to the same standard brain atlas. Strain field correlations (Cv), both global (over the brain volume) and local (over smaller sub-volumes), are then computed from the inner product of the complex-valued strain tensors from model and experiment at each voxel. To demonstrate our approach, we compare strain fields from MRE in six human subjects to predictions from two previously developed models. Notably, global Cv values are higher when comparing strain fields from different subjects (Cv~0.6–0.7) than when comparing strain fields from either of the two models to strain fields in any subject. The proposed framework provides a quantitative method to assess similarity (and to identify discrepancies) between model predictions and experimental measurements of brain deformation and thus can aid in the development and evaluation of improved models of brain biomechanics.
AB - We propose a robust framework for quantitatively comparing model-predicted and experimentally measured strain fields in the human brain during harmonic skull motion. Traumatic brain injuries (TBIs) are typically caused by skull impact or acceleration, but how skull motion leads to brain deformation and consequent neural injury remains unclear and comparison of model predictions to experimental data remains limited. Magnetic resonance elastography (MRE) provides high-resolution, full-field measurements of dynamic brain deformation induced by harmonic skull motion. In the proposed framework, full-field strain measurements from human brain MRE in vivo are compared to simulated strain fields from models with similar harmonic loading. To enable comparison, the model geometry and subject anatomy, and subsequently, the predicted and measured strain fields are nonlinearly registered to the same standard brain atlas. Strain field correlations (Cv), both global (over the brain volume) and local (over smaller sub-volumes), are then computed from the inner product of the complex-valued strain tensors from model and experiment at each voxel. To demonstrate our approach, we compare strain fields from MRE in six human subjects to predictions from two previously developed models. Notably, global Cv values are higher when comparing strain fields from different subjects (Cv~0.6–0.7) than when comparing strain fields from either of the two models to strain fields in any subject. The proposed framework provides a quantitative method to assess similarity (and to identify discrepancies) between model predictions and experimental measurements of brain deformation and thus can aid in the development and evaluation of improved models of brain biomechanics.
KW - Brain simulation
KW - Frequency-domain comparison
KW - Magnetic resonance elastography
KW - Nonlinear registration
KW - Strain fields
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85212525297&partnerID=8YFLogxK
U2 - 10.1007/s10237-024-01913-8
DO - 10.1007/s10237-024-01913-8
M3 - Article
C2 - 39704895
AN - SCOPUS:85212525297
SN - 1617-7959
JO - Biomechanics and Modeling in Mechanobiology
JF - Biomechanics and Modeling in Mechanobiology
M1 - 081006
ER -