Fueling the fire with fibers: Bacterial amyloids promote inflammatory disorders

Caitlin N. Spaulding; Karen W. Dodson; Matthew R. Chapman; Scott J. Hultgren

doi:10.1016/j.chom.2015.06.013

Fueling the fire with fibers: Bacterial amyloids promote inflammatory disorders

Caitlin N. Spaulding
, Karen W. Dodson
, Matthew R. Chapman
, Scott J. Hultgren

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.

Original language	English
Pages (from-to)	1-2
Number of pages	2
Journal	Cell Host and Microbe
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.chom.2015.06.013
State	Published - 2015

Access to Document

10.1016/j.chom.2015.06.013

Cite this

@article{98be42e1494a487d8c9db2a24277b9a5,

title = "Fueling the fire with fibers: Bacterial amyloids promote inflammatory disorders",

abstract = "Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.",

author = "Spaulding, \{Caitlin N.\} and Dodson, \{Karen W.\} and Chapman, \{Matthew R.\} and Hultgren, \{Scott J.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

doi = "10.1016/j.chom.2015.06.013",

language = "English",

volume = "18",

pages = "1--2",

journal = "Cell Host and Microbe",

issn = "1931-3128",

number = "1",

}

TY - JOUR

T1 - Fueling the fire with fibers

T2 - Bacterial amyloids promote inflammatory disorders

AU - Spaulding, Caitlin N.

AU - Dodson, Karen W.

AU - Chapman, Matthew R.

AU - Hultgren, Scott J.

PY - 2015

Y1 - 2015

N2 - Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.

AB - Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.

UR - https://www.scopus.com/pages/publications/84941556589

U2 - 10.1016/j.chom.2015.06.013

DO - 10.1016/j.chom.2015.06.013

M3 - Short survey

C2 - 26159711

AN - SCOPUS:84941556589

SN - 1931-3128

VL - 18

SP - 1

EP - 2

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 1

ER -

Fueling the fire with fibers: Bacterial amyloids promote inflammatory disorders

Abstract

Access to Document

Other files and links

Fingerprint

Cite this