Fueling the fire with fibers: Bacterial amyloids promote inflammatory disorders

Caitlin N. Spaulding, Karen W. Dodson, Matthew R. Chapman, Scott J. Hultgren

Research output: Contribution to journalShort surveypeer-review

16 Scopus citations

Abstract

Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.

Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalCell Host and Microbe
Volume18
Issue number1
DOIs
StatePublished - 2015

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