TY - JOUR
T1 - Fueling the fire with fibers
T2 - Bacterial amyloids promote inflammatory disorders
AU - Spaulding, Caitlin N.
AU - Dodson, Karen W.
AU - Chapman, Matthew R.
AU - Hultgren, Scott J.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.
AB - Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.
UR - http://www.scopus.com/inward/record.url?scp=84941556589&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2015.06.013
DO - 10.1016/j.chom.2015.06.013
M3 - Short survey
C2 - 26159711
AN - SCOPUS:84941556589
SN - 1931-3128
VL - 18
SP - 1
EP - 2
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 1
ER -