FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia

Parviz K. Kavoussi, Kayla Hudson, G. Luke Machen, Maya Barsky, Dan I. Lebovic, Shahryar K. Kavoussi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Purpose: The purpose of this study is to assess a potential association between FSH levels and testicular volumes with the severity of testicular histopathology on testicular biopsy in men with non-obstructive azoospermia (NOA) undergoing microdissection testicular sperm extraction (microTESE). Methods: A retrospective chart review was performed from the electronic health records of men who underwent microTESE with NOA. Results: Eighty-six men with NOA underwent microTESE with concomitant testicular biopsy for permanent section to assess the testicular cellular architecture. The histopathological patterns were categorized by severity indicating the odds of sperm retrieval into 2 categories. The unfavorable category included Sertoli cell only pattern and early maturation arrest (n = 50) and the favorable category included late maturation arrest and hypospermatogenesis patterns (n = 36). In the men with unfavorable histopathologic patterns, the mean FSH level was 22.9 ± 16.6 IU/L, and the mean testicular volume was 10.4 ± 6.0 cc. This was in comparison to men with favorable histopathologic patterns revealing a mean FSH level of FSH 13.3 ± 12.0 with a mean testicular volume of 13.3 ± 5.9 cc. There was a statistically significant higher FSH level in men with unfavorable histopathology than favorable (p = 0.004) as well as a significant smaller mean testicular volume in men with unfavorable histopathology (p = 0.029). Conclusions: Higher serum FSH levels and smaller testicular volumes are associated with more severe testicular histopathological patterns in men with NOA.

Original languageEnglish
Pages (from-to)3015-3018
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Volume38
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Follicle stimulating hormone
  • Histopathology
  • Non obstructive azoospermia
  • Testicular volume

Fingerprint

Dive into the research topics of 'FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia'. Together they form a unique fingerprint.

Cite this