TY - JOUR
T1 - Frontotemporal Dementias in Latin America
T2 - History, Epidemiology, Genetics, and Clinical Research
AU - Llibre-Guerra, Jorge J.
AU - Behrens, Maria Isabel
AU - Hosogi, Mirna Lie
AU - Montero, Lucia
AU - Torralva, Teresa
AU - Custodio, Nilton
AU - Longoria-Ibarrola, Erika Mariana
AU - Giraldo-Chica, Margarita
AU - Aguillón, David
AU - Hardi, Angela
AU - Maestre, Gladys E.
AU - Contreras, Valeria
AU - Doldan, Celeste
AU - Duque-Peñailillo, Lissette
AU - Hesse, Heike
AU - Roman, Norbel
AU - Santana-Trinidad, Dhara Angelina
AU - Schenk, Christian
AU - Ocampo-Barba, Ninoska
AU - López-Contreras, Ricardo
AU - Nitrini, Ricardo
N1 - Publisher Copyright:
© Copyright © 2021 Llibre-Guerra, Behrens, Hosogi, Montero, Torralva, Custodio, Longoria-Ibarrola, Giraldo-Chica, Aguillón, Hardi, Maestre, Contreras, Doldan, Duque-Peñailillo, Hesse, Roman, Santana-Trinidad, Schenk, Ocampo-Barba, López-Contreras and Nitrini.
PY - 2021/9/6
Y1 - 2021/9/6
N2 - Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries. Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings. Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD. Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.
AB - Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries. Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings. Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD. Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.
KW - Latin America
KW - biomarkers
KW - frontotemporal dementia
KW - genetics
KW - history
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=85115385421&partnerID=8YFLogxK
U2 - 10.3389/fneur.2021.710332
DO - 10.3389/fneur.2021.710332
M3 - Review article
C2 - 34552552
AN - SCOPUS:85115385421
SN - 1664-2295
VL - 12
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 710332
ER -