TY - JOUR
T1 - From physiology to pharmacy
T2 - Developments in the pathogenesis and treatment of recurrent urinary tract infections
AU - Silverman, Jennifer A.
AU - Schreiber, Henry L.
AU - Hooton, Thomas M.
AU - Hultgren, Scott J.
N1 - Funding Information:
Dr. Scott J. Hultgren was supported by grants from NIAID R01 AI029549, NIAID R01 AI048689, ORWH NIDDK P50 DK064540, NIDDK R01 DK051406, NIAID U01 AI095542, and NIAID R01 AI099099. Dr. Hultgren has a board membership, and owns stock in Fimbrion Therapeutics, Inc.
PY - 2013/10
Y1 - 2013/10
N2 - Urinary tract infections (UTIs) are common, and over half of women report having had at least one in their lifetime. Nearly a third of these women experience recurrent UTI episodes, but the mechanisms of these recurrences are not fully elucidated. Frequent use of antimicrobials for treatment and prevention of UTIs and other infections has contributed to the evolution of multidrug-resistant microorganisms globally. This is a looming worldwide crisis that has created an urgent need for novel strategies for the treatment and prevention of UTIs. Furthering our understanding of the mechanisms of recurrent UTIs, from both host and bacterial perspectives, will be paramount in developing targeted management strategies. In this review, we discuss recent findings regarding recurrent UTIs in women, including progress in our understanding of the mechanisms of recurrence as well as emerging treatments.
AB - Urinary tract infections (UTIs) are common, and over half of women report having had at least one in their lifetime. Nearly a third of these women experience recurrent UTI episodes, but the mechanisms of these recurrences are not fully elucidated. Frequent use of antimicrobials for treatment and prevention of UTIs and other infections has contributed to the evolution of multidrug-resistant microorganisms globally. This is a looming worldwide crisis that has created an urgent need for novel strategies for the treatment and prevention of UTIs. Furthering our understanding of the mechanisms of recurrent UTIs, from both host and bacterial perspectives, will be paramount in developing targeted management strategies. In this review, we discuss recent findings regarding recurrent UTIs in women, including progress in our understanding of the mechanisms of recurrence as well as emerging treatments.
KW - Antibiotic resistance
KW - FimH
KW - Mannoside
KW - Pilicide
KW - Recurrent urinary tract infection
KW - Stress response
UR - http://www.scopus.com/inward/record.url?scp=84886772177&partnerID=8YFLogxK
U2 - 10.1007/s11934-013-0354-5
DO - 10.1007/s11934-013-0354-5
M3 - Article
C2 - 23832844
AN - SCOPUS:84886772177
SN - 1527-2737
VL - 14
SP - 448
EP - 456
JO - Current Urology Reports
JF - Current Urology Reports
IS - 5
ER -