From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates

Riadh Cheddadi, Venkata Yeramilli, Colin Martin

Research output: Contribution to journalReview articlepeer-review


The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between microbiome alterations and severe conditions, prompting the development of new frameworks through epidemiological studies. Traditionally, it was believed that each individual harbored unique microbial communities acquired early in life, evolving over the course of their lifetime, with little acknowledgment of any prenatal microbial development, but recent research challenges this belief. The neonatal microbiome’s onset, influenced by factors like delivery mode and maternal health, remains a subject of intense debate, hinting at potential intrauterine microbial processes. In-depth research reveals associations between microbiome profiles and specific health outcomes, ranging from obesity to neurodevelopmental disorders. Understanding these diverse microbiome profiles is essential for unraveling the intricate relationships between the microbiome and health outcomes.

Original languageEnglish
Article number1184
Issue number12
StatePublished - Dec 2023


  • animal models
  • maternal influence
  • maternal microbiome
  • metabolites
  • microbiome transfer
  • neonatal microbiome
  • omics
  • pregnancy


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