From IL-10 to IL-12: How pathogens and their products stimulate APCs to induce TH1 development

Anne O'Garra; Kenneth M. Murphy

doi:10.1038/ni0909-929

From IL-10 to IL-12: How pathogens and their products stimulate APCs to induce T_H1 development

Anne O'Garra, Kenneth M. Murphy

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T_H1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T_H1 cells.

Original language	English
Pages (from-to)	929-932
Number of pages	4
Journal	Nature immunology
Volume	10
Issue number	9
DOIs	https://doi.org/10.1038/ni0909-929
State	Published - 2009

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abstract = "The authors recount their discovery of how pathogen-induced interleukin 12 production leads to TH1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of TH1 cells.",

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From IL-10 to IL-12: How pathogens and their products stimulate APCs to induce T_H1 development

Abstract

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