From genes to treatments: A systematic review of the pharmacogenetics in smoking cessation

Naji C. Salloum, Erica Lf Buchalter, Swati Chanani, Gemma Espejo, Mahjabeen S. Ismail, Randy O. Laine, Maysaa Nageeb, A. Benjamin Srivastava, Nicholas Trapp, Ludwig Trillo, Erica Vance, Michael Wenzinger, Sarah M. Hartz, Sean P. David, Li Shiun Chen

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Smoking cessation treatment outcomes may be heavily influenced by genetic variations among smokers. Therefore, identifying specific variants that affect response to different pharmacotherapies is of major interest to the field. In the current study, we systematically review all studies published in or after the year 1990 which examined one or more gene-drug interactions for smoking cessation treatment. Out of 644 citations, 46 articles met the inclusion criteria for the systematic review. We summarize evidence on several genetic polymorphisms (CHRNA5-A3-B4, CYP2A6, DBH, CHRNA4, COMT, DRD2, DRD4 and CYP2B6) and their potential moderating pharamacotherarpy effects on patient cessation efficacy rates. These findings are promising and call for further research to demonstrate the effectiveness of genetic testing in personalizing treatment decision-making and improving outcome.

Original languageEnglish
Pages (from-to)861-871
Number of pages11
JournalPharmacogenomics
Volume19
Issue number10
DOIs
StatePublished - Jan 1 2018

Keywords

  • nicotine replacement therapy
  • pharmacogenetics
  • precision medicine
  • smoking cessation

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    Salloum, N. C., Buchalter, E. L., Chanani, S., Espejo, G., Ismail, M. S., Laine, R. O., Nageeb, M., Srivastava, A. B., Trapp, N., Trillo, L., Vance, E., Wenzinger, M., Hartz, S. M., David, S. P., & Chen, L. S. (2018). From genes to treatments: A systematic review of the pharmacogenetics in smoking cessation. Pharmacogenomics, 19(10), 861-871. https://doi.org/10.2217/pgs-2018-0023