TY - JOUR
T1 - From Alpha to Omicron and Beyond
T2 - Associations Between SARS-CoV-2 Variants and Surgical Outcomes
AU - N3C Consortium
AU - Verhagen, Nathaniel B.
AU - Geissler, Thomas
AU - SenthilKumar, Gopika
AU - Gehl, Carson
AU - Shaik, Tahseen
AU - Flitcroft, Madelyn A.
AU - Yang, Xin
AU - Taylor, Bradley W.
AU - Ghaferi, Amir A.
AU - Gould, Jon C.
AU - Kothari, Anai N.
AU - Wilcox, Adam B.
AU - Lee, Adam M.
AU - Graves, Alexis
AU - Anzalone, Alfred
AU - Manna, Amin
AU - Saha, Amit
AU - Olex, Amy
AU - Zhou, Andrea
AU - Williams, Andrew E.
AU - Southerland, Andrew
AU - Girvin, Andrew T.
AU - Walden, Anita
AU - Sharathkumar, Anjali A.
AU - Amor, Benjamin
AU - Bates, Benjamin
AU - Hendricks, Brian
AU - Patel, Brijesh
AU - Alexander, Caleb
AU - Bramante, Carolyn
AU - Ward-Caviness, Cavin
AU - Madlock-Brown, Charisse
AU - Suver, Christine
AU - Chute, Christopher
AU - Dillon, Christopher
AU - Wu, Chunlei
AU - Schmitt, Clare
AU - Takemoto, Cliff
AU - Housman, Dan
AU - Gabriel, Davera
AU - Eichmann, David A.
AU - Mazzotti, Diego
AU - Brown, Don
AU - Boudreau, Eilis
AU - Hill, Elaine
AU - Zampino, Elizabeth
AU - Marti, Emily Carlson
AU - Pfaff, Emily R.
AU - French, Evan
AU - Koraishy, Farrukh M.
AU - Mariona, Federico
AU - Prior, Fred
AU - Sokos, George
AU - Martin, Greg
AU - Lehmann, Harold
AU - Spratt, Heidi
AU - Mehta, Hemalkumar
AU - Liu, Hongfang
AU - Sidky, Hythem
AU - Hayanga, J. W.Awori
AU - Pincavitch, Jami
AU - Clark, Jaylyn
AU - Harper, Jeremy Richard
AU - Islam, Jessica
AU - Ge, Jin
AU - Gagnier, Joel
AU - Saltz, Joel H.
AU - Saltz, Joel
AU - Loomba, Johanna
AU - Buse, John
AU - Mathew, Jomol
AU - Rutter, Joni L.
AU - McMurry, Julie A.
AU - Guinney, Justin
AU - Starren, Justin
AU - Crowley, Karen
AU - Bradwell, Katie Rebecca
AU - Walters, Kellie M.
AU - Wilkins, Ken
AU - Gersing, Kenneth R.
AU - Cato, Kenrick Dwain
AU - Murray, Kimberly
AU - Kostka, Kristin
AU - Northington, Lavance
AU - Pyles, Lee Allan
AU - Misquitta, Leonie
AU - Cottrell, Lesley
AU - Portilla, Lili
AU - Deacy, Mariam
AU - Bissell, Mark M.
AU - Clark, Marshall
AU - Emmett, Mary
AU - Saltz, Mary Morrison
AU - Palchuk, Matvey B.
AU - Haendel, Melissa A.
AU - Adams, Meredith
AU - Temple-O'Connor, Meredith
AU - Kurilla, Michael G.
AU - Morris, Michele
AU - Qureshi, Nabeel
AU - Safdar, Nasia
AU - Garbarini, Nicole
AU - Sharafeldin, Noha
AU - Sadan, Ofer
AU - Francis, Patricia A.
AU - Burgoon, Penny Wung
AU - Robinson, Peter
AU - Payne, Philip R.O.
AU - Fuentes, Rafael
AU - Jawa, Randeep
AU - Erwin-Cohen, Rebecca
AU - Patel, Rena
AU - Moffitt, Richard A.
AU - Zhu, Richard L.
AU - Kamaleswaran, Rishi
AU - Hurley, Robert
AU - Miller, Robert T.
AU - Pyarajan, Saiju
AU - Michael, Sam G.
AU - Bozzette, Samuel
AU - Mallipattu, Sandeep
AU - Vedula, Satyanarayana
AU - Chapman, Scott
AU - O'Neil, Shawn T.
AU - Setoguchi, Soko
AU - Hong, Stephanie S.
AU - Johnson, Steve
AU - Bennett, Tellen D.
AU - Callahan, Tiffany
AU - Topaloglu, Umit
AU - Sheikh, Usman
AU - Gordon, Valery
AU - Subbian, Vignesh
AU - Kibbe, Warren A.
AU - Hernandez, Wenndy
AU - Beasley, Will
AU - Cooper, Will
AU - Hillegass, William
AU - Zhang, Xiaohan Tanner
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/9
Y1 - 2024/9
N2 - Introduction: The COVID-19 pandemic has significantly influenced surgical practices, with SARS-CoV-2 variants presenting unique pathologic profiles and potential impacts on perioperative outcomes. This study explores associations between Alpha, Delta, and Omicron variants of SARS-CoV-2 and surgical outcomes. Methods: We conducted a retrospective analysis using the National COVID Cohort Collaborative database, which included patients who underwent selected major inpatient surgeries within eight weeks post–SARS-CoV-2 infection from January 2020 to April 2023. The viral variant was determined by the predominant strain at the time of the patient's infection. Multivariable logistic regression models explored the association between viral variants, COVID-19 severity, and 30-d major morbidity or mortality. Results: The study included 10,617 surgical patients with preoperative COVID-19, infected by the Alpha (4456), Delta (1539), and Omicron (4622) variants. Patients infected with Omicron had the highest vaccination rates, most mild disease, and lowest 30-d morbidity and mortality rates. Multivariable logistic regression demonstrated that Omicron was linked to a reduced likelihood of adverse outcomes compared to Alpha, while Delta showed odds comparable to Alpha. Inclusion of COVID-19 severity in the model rendered the odds of major morbidity or mortality equal across all three variants. Conclusions: Our study examines the associations between the clinical and pathological characteristics of SARS-CoV-2 variants and surgical outcomes. As novel SARS-CoV-2 variants emerge, this research supports COVID-19–related surgical policy that assesses the severity of disease to estimate surgical outcomes.
AB - Introduction: The COVID-19 pandemic has significantly influenced surgical practices, with SARS-CoV-2 variants presenting unique pathologic profiles and potential impacts on perioperative outcomes. This study explores associations between Alpha, Delta, and Omicron variants of SARS-CoV-2 and surgical outcomes. Methods: We conducted a retrospective analysis using the National COVID Cohort Collaborative database, which included patients who underwent selected major inpatient surgeries within eight weeks post–SARS-CoV-2 infection from January 2020 to April 2023. The viral variant was determined by the predominant strain at the time of the patient's infection. Multivariable logistic regression models explored the association between viral variants, COVID-19 severity, and 30-d major morbidity or mortality. Results: The study included 10,617 surgical patients with preoperative COVID-19, infected by the Alpha (4456), Delta (1539), and Omicron (4622) variants. Patients infected with Omicron had the highest vaccination rates, most mild disease, and lowest 30-d morbidity and mortality rates. Multivariable logistic regression demonstrated that Omicron was linked to a reduced likelihood of adverse outcomes compared to Alpha, while Delta showed odds comparable to Alpha. Inclusion of COVID-19 severity in the model rendered the odds of major morbidity or mortality equal across all three variants. Conclusions: Our study examines the associations between the clinical and pathological characteristics of SARS-CoV-2 variants and surgical outcomes. As novel SARS-CoV-2 variants emerge, this research supports COVID-19–related surgical policy that assesses the severity of disease to estimate surgical outcomes.
KW - COVID-19
KW - Postoperative outcomes
KW - SARS-CoV-2
KW - Variant
UR - http://www.scopus.com/inward/record.url?scp=85196552579&partnerID=8YFLogxK
U2 - 10.1016/j.jss.2024.05.034
DO - 10.1016/j.jss.2024.05.034
M3 - Article
C2 - 38917576
AN - SCOPUS:85196552579
SN - 0022-4804
VL - 301
SP - 71
EP - 79
JO - Journal of Surgical Research
JF - Journal of Surgical Research
ER -