TY - JOUR
T1 - Friend or foe
T2 - The protective and pathological roles of inducible bronchus-associated lymphoid tissue in pulmonary diseases
AU - Marin, Nancy D.
AU - Dunlap, Micah D.
AU - Kaushal, Deepak
AU - Khader, Shabaana A.
N1 - Funding Information:
This work was supported by Washington University in St Louis; National Institutes of Health (NIH) Grants R01 AI134236, R01 AI111914, R01 HL105427, and R01 AI123780; and NIH/National Heart, Lung, and Blood Institute Training Grant T32 AI007172 (to M.D.D.).
Publisher Copyright:
Copyright © 2019 by The American Association of Immunologists, Inc.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Inducible bronchus-associated lymphoid tissue (iBALT) is a tertiary lymphoid structure that resembles secondary lymphoid organs. iBALT is induced in the lung in response to Ag exposure. In some cases, such as infection with Mycobacterium tuberculosis, the formation of iBALT structure is indicative of an effective protective immune response. However, with persistent exposure to Ags during chronic inflammation, allergy, or autoimmune diseases, iBALT may be associated with exacerbation of inflammation. iBALT is characterized by well-organized T and B areas enmeshed with conventional dendritic cells, follicular dendritic cells, and stromal cells, usually located surrounding airways or blood vessels. Several of the molecular signals and cellular contributors that mediate formation of iBALT structures have been recently identified. This review will outline the recent findings associated with the formation and maintenance of iBALT and their contributions toward a protective or pathogenic function in pulmonary disease outcome.
AB - Inducible bronchus-associated lymphoid tissue (iBALT) is a tertiary lymphoid structure that resembles secondary lymphoid organs. iBALT is induced in the lung in response to Ag exposure. In some cases, such as infection with Mycobacterium tuberculosis, the formation of iBALT structure is indicative of an effective protective immune response. However, with persistent exposure to Ags during chronic inflammation, allergy, or autoimmune diseases, iBALT may be associated with exacerbation of inflammation. iBALT is characterized by well-organized T and B areas enmeshed with conventional dendritic cells, follicular dendritic cells, and stromal cells, usually located surrounding airways or blood vessels. Several of the molecular signals and cellular contributors that mediate formation of iBALT structures have been recently identified. This review will outline the recent findings associated with the formation and maintenance of iBALT and their contributions toward a protective or pathogenic function in pulmonary disease outcome.
UR - http://www.scopus.com/inward/record.url?scp=85065114375&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1801135
DO - 10.4049/jimmunol.1801135
M3 - Review article
C2 - 31010841
AN - SCOPUS:85065114375
SN - 0022-1767
VL - 202
SP - 2519
EP - 2526
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -