Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells

Meixia Zhou, Wenjun Ouyang, Qian Gong, Samuel G. Katz, J. Michael White, Stuart H. Orkin, Kenneth M. Murphy

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The development of naive CD4+ T cells into a T helper (Th) 2 subset capable of producing interleukin (IL)-4. IL-5, and IL-13 involves a signal transducer and activator of transcription (Stat)6-dependent induction of GATA-3 expression, followed by Stat6-independent GATA-3 autoactivation. The friend of GATA (FOG)-1 protein regulates GATA transcription factor activity in several stages of hematopoietic development including erythrocyte and megakaryocyte differentiation, but whether FOG-1 regulates GATA-3 in T cells is uncertain. We show that FOG-1 can repress GATA-3-dependent activation of the IL-5 promoter in T cells. Also, FOG-1 overexpression during primary activation of naive T cells inhibited Th2 development in CD4+ T cells. FOG-1 fully repressed GATA-3-dependent Th2 development and GATA-3 autoactivation, but not Stat6-dependent induction of GATA-3. FOG-1 overexpression repressed development of Th2 cells from naive T cells, but did not reverse the phenotype of fully committed Th2 cells. Thus, FOG-1 may be one factor capable of regulating the Th2 development.

Original languageEnglish
Pages (from-to)1461-1471
Number of pages11
JournalJournal of Experimental Medicine
Issue number10
StatePublished - Nov 19 2001


  • Cytokine
  • FOG-1
  • GATA-3
  • T lymphocyte
  • Thymocyte

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    Zhou, M., Ouyang, W., Gong, Q., Katz, S. G., White, J. M., Orkin, S. H., & Murphy, K. M. (2001). Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. Journal of Experimental Medicine, 194(10), 1461-1471.